田志刚教授

生命科学学院

电子邮箱

瀚海星云BBS

CMI杂志

中国科学技术大学

首页教授风采旧

田志刚教授

实验室网站http://ioi.ustc.edu.cn/tzg_lab

教授、博士生导师，中国工程院院士。中国科学技术大学生命科学与医学部基础医学院院长，免疫学研究所所长，中国科学院天然免疫与慢性疾病重点实验室主任。任中国免疫学会监事长、曾任中国免疫学会理事长、国务院学位办学科评议组专家、国家基金委医学部咨询委员会委员。历任山东省医学科学院基础医学所所长（1996-2001），山东肿瘤生物治疗研究中心副主任、主任（1989-2001），中国免疫学会副理事长（2005-2014），中国科技大学生命科学学院副院长、院长（2005-2014）。1982年山西医科大学医学本科， 1985年山东省医学科学院免疫学硕士，1989年白求恩医科大学免疫学博士毕业。1994-2001年之间作为访问学者多次短期赴美国NIH国立癌症研究所工作，曾任日本金泽大学国立癌研所访问教授（2001-2002）。2001年国家杰出青年科学基金获得者、2008和2011年国家基金委创新群体负责人、2008和2011年国家科技重大专项项目负责人、2012年国家重大研究计划项目首席科学家。

2003年创办、承办并作为执行主编运行中国免疫学会英文会刊（Cell Mol Immunol）；为《中国免疫学杂志》主编，《Cytokine》、《中国肿瘤生物治疗杂志》等刊物副主编。以通讯作者在Cell、Nat Immunol、Immunity、J Exp Med、J Clin Invest、Nat Commune、PNAS、Gastroenterology、Hepatology等发表SCI论文200余篇。2008年获国家自然科学二等奖（首位）、2011年获国家科技进步二等奖（第二位）。在美、德、日、加等参加国际会议或访问作学术报告30余次。获国家发明专利授权20余项。

主要科研兴趣:
1．NK细胞生物学研究;
2．肝脏免疫学研究;
3．NK细胞为基础的新型生物治疗技术及产品研制。

代表性论文:

1. Chen Y, Tian Z, Peng H*.Immunological memory: ILC1s come into view.Cell Mol Immunol. 2019 Dec;16(12):895-896.

2. Bai L, Peng H*, Hao X, Tang L, Sun C, Zheng M, Liu F, Lian Z, Bai L, Wei H, Sun R*, Tian Z*.CD8⁺ T Cells Promote Maturation of Liver-Resident NK Cells via the CD70-CD27 axis. Hepatology. 2019 Nov;70(5):1804-1815.

3. Wang X, Sun R, Hao X, Lian Z, Wei H, Tian Z*. IL-17 constrains natural killer cell activity by restraining IL-15-driven cell maturation via SOCS3. PNAS. 2019 Aug 27;116(35):17409-17418.

4. Wang B, Zhou J, Chen Y, Wei H, Sun R, Tian Z*, Peng H*. A novel spleen-resident immature NK cell subset and its maturation in a T-bet-dependent manner. J Autoimmun. 2019 Jul 24:102307.

5. Sun H*, Liu L, Huang Q, Liu H, Huang M, Wang J, Wen H, Lin R, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z*, Sun C*. Accumulation of tumor-infiltrating CD49a+ NK cells correlates with poor prognosis for human hepatocellular carcinoma.Cancer Immunol Res. 2019 Sep;7(9):1535-1546.

6. Sun H, Huang Q, Huang M, Wen H, Lin R, Zheng M, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z*, Sun C* . Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma. Hepatology. 2019 Jul;70(1):168-183.

7. Chen Y*, Hao X, Sun R, Wei H, Tian Z*. NK cell-derived IFN-γ promotes hepatocellular carcinoma through EpCAM-EMT axis in hepatitis B virus transgenic mice. Hepatology. 2019 Apr;69(4):1735-1750.

8. Zhou J, Peng H*, Li K, Qu K, Wang B, Wu Y, Ye L, Dong Z, Wei H, Sun R, Tian Z*.Liver-resident NK cells control antiviral activity of hepatic T cells via PD-1/PD-L1 axis. Immunity. 2019 Feb 19;50(2):403-417.

9. Zong L, Peng H , Sun C, Li F, Zheng M, Chen Y, Wei H, Sun R, Tian Z*.Breakdown of adaptiveimmunotolerance induces hepatocellular carcinoma in HBsAg-tg mice.Nat Commun. 2019 Jan 15;10(1):221.

10. Sun H, Xu J, Huang Q, Huang M, Li K, Qu K, Wen H, Lin R, Zheng M, Wei H, Xiao W, Sun R, Tian Z*, Sun C*. Reduced CD160 expression contributes to impaired NK cell function and poor clinical outcomes in patients with HCC. Cancer Res. 2018 Dec 1;78(23):6581-6593.

11. Wang X, Peng H*, Cong J, Wang X, Lian Z, Wei H, Sun R*, Tian Z*.Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis. Nat Commun. 2018 Nov 19;9(1):4854.

12. Huang C, Wang J*, Zheng X, Chen Y, Zhou R, Wei H, Sun R, Tian Z*. Commensal bacteria aggravate allergic asthma via NLRP3/IL-1β signaling in post-weaning mice. J Autoimmun. 2018 Sep; 93:104-113.

13. Cong J, Wang X, Zheng X, Wang D, Fu B, Sun R, Tian Z*, Wei H*.Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression. Cell Metab.2018 Aug 7: 28(2):243-255.

14. Zhang Q, Bi J, Zheng X, Chen Y, Wang H, Wu W, Wang Z, Wu Q, Peng H, Wei H, Sun R*, Tian Z*. Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nat Immunol. 2018 Jun 18;723–732 .

15. Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G ,Song J,Wang J, Wei H, Zhang J,Sun R, Zhang C*,Tian Z*. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nat Commun. 2018 Mar 28;9(1):1241.

16. Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z*, Wei H*. Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors. Immunity. 2017 Dec 19;47(6):1100-1113.

17. Li F, Hao X, Chen Y, Bai L, Gao X, Lian Z, Wei H, Sun R, Tian Z*. Microbiota maintains homeostasis of liver-resident γδT-17 cells in a lipid antigen-CD1d–dependent manner. Nat Commun. 2017 Jan 9;7:13839

18. Chen S, Yang M, Du J, Li D, Li Z, Cai C, Ma Y, Zhang L, Tian Z*, Dong Z*. The Self-Specific Activation Receptor SLAM Family Is Critical for NK Cell Education. Immunity. 2016 Aug 16;45(2):292-304.

19. Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z*, Zhou R*. Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome. Cell. 2015 Jan 15;160(1-2):62-73.

20. Tian Z*. Outflanking HCV. Nat Immunol.2014;15:6-8.

21. Yang M, Li D, Chang Z, Yang Z, Tian Z, Dong Z*. PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness. J Exp Med. 2015 Feb 9;212(2):253-65.

22. Wang J, Li F, Wei H, Lian Z-X, Sun R, Tian Z*. Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation. J Exp Med. 2014;211:2397-2410.

23. Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G,Tian Z*, Tschopp J, Zhou R*. Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation. Immunity.2013;38:1154-1163.

24. Jiang W, Wang X, Zeng B, Liu L, Tardivel A, Wei H, Han J, MacDonald HR, Tschopp J, Tian Z*, Zhou R*. Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. J Exp Med. 2013;210:2465-2476.

25. Peng H, Jiang X, Chen Y, Sojka DK, Wei H, Gao X, Sun R, Yokoyama WM, Tian Z*. Liver-resident NK cells confer adaptive immunity in skin-contact inflammation. Journal of Clinical Investigation. 2013;123:1444-1456.

26. Li F, Wei H*, Wei H, Gao Y, Xu L, Yin W, Sun R, Tian Z*. Blocking the Natural Killer Cell Inhibitory Receptor NKG2A Increases Activity of Human Natural Killer Cells and Clears Hepatitis B Virus Infection in Mice. Gastroenterology.2013;144:392-401.

27. Xu L, Yin W, Sun R, Wei H, Tian Z*. Liver type I regulatory T cells suppress germinal center formation in HBV-tolerant mice. PNAS. 2013;110:16993-16998.