孙汭教授 | ||
主要研究兴趣: 1. NK 细胞的天然免疫识别 2. NK/NKT细胞在肝脏再生与损伤中的作用机理
主要代表论文: 1. Bai L, Peng H*, Hao X, Tang L, Sun C, Zheng M, Liu F, Lian Z, Bai L, Wei H, Sun R*, Tian Z*.CD8+ T Cells Promote Maturation of Liver-Resident NK Cells via the CD70-CD27 axis.Hepatology. 2019 Nov;70(5):1804-1815. 2. Zhang Q, Bi J, Zheng X, Chen Y, Wang H,Wu W, Wang Z, Wu Q, Peng H, Wei H, Sun R*, Tian Z*.Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nat Immunol.2018,19:723–732. 3. Wang X, Peng H*,Cong J, Wang X, Lian Z,Wei H, Sun R*& Tian Z*. Memory formation and long-term maintenance of IL-7Rα+ILC1s via a lymph node-liver axis.Nat Commun.2018;9:4854. 4. Li T, Wang J*, Wang Y, Chen Y, Wei H, Sun R*, Tian Z*. Respiratory Influenza Virus Infection Induces Memory-like Liver NK Cells in Mice.J Immunol.2017Feb 1;198(3):1242-1252. 5. He Y, Peng H, Sun R*, Wei H, Ljunggren HG, Yokoyama WM, Tian Z*. Contributionof inhibitory receptor TIGIT to NK cell education. J Autoimmun.2017 Jul;81:1-12. 6. Jiang W, Sun R, Wei H, Zhou R, Tian Z. Toll-like receptor 9 activation aggravates Con A-inducedhepatitis via promoting accumulation and activation of liver CD4+ NKT cells. J Immunol. 2009; 182:3768-74 7. Sun R, Park O, Horiguchi N, Kulkarni S, Jeong W-IL, Sun HY, Radaeva S and Gao B. STAT1 contributes to dsRNA inhibition if liver regeneration after partial hepatectomy in mice. Hepatology. 2006; 44: 955-966. 8. Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B. Natural Killer Cells Ameliorate Liver Fibrosis by Killing Activated Stellate Cells in NKG2D- dependent and tumour necrosis factor-related apoptosis-inducing ligand-dependent manners. Ganstroenterology. 2006; 130: 435-452 9. Sun R, Jaruga B, Kulkarni S, Sun HY and Gao B. IL-6modulates hepatocyte proliferation via inducytion of HCF/p21cip1: Regulation by SOCS3. Biochemical and Biophysical Research Communication. 2005; 338: 1943-1949 10.Sun R, Gao B. Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-gamma). Gastroenterology. 2004 Nov;127(5):1525-39.
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