近期发表文章：
1. Zheng X* , Hou Z, Qian Y, Zhang Y, Cui Q, Wang X, Shen Y, Liu Z, Zhou Y, Fu B, Sun R, Tian Z* , Huang G*, Wei H*. Tumors evade immune cytotoxicity by altering the surface topology of NK cells. Nat Immunol. 2023 May;24(5):802-813. 2. Bai L, Vienne M, Tang L, Kerdiles Y, Etiennot M, Escalière B, Galluso J, Wei H, Sun R, Vivier E, Peng H*, Tian Z*. Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop. Science. 2021 Mar 26;371(6536):eaba4177. 3. Shen Y, Zheng X, Qian Y, Liu M, Nian Z, Cui Q, Zhou Y, Fu B, Sun R*, Tian Z*, Wei H*. Interactions between driver genes shape the signaling pathway landscape and direct hepatocellular carcinoma therapy. Cancer Sci. 2023 Mar 15. doi: 10.1111/cas.15788. 4. Wang D#, Li X#, Jiao D, Cai Y, Qian L, Shen Y, Lu Y, Zhou Y, Fu B, Sun R, Tian Z, Zheng X*, Wei H*. LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia. J Hematol Oncol. 2023 Mar 27;16(1):30. 5. Bi J*, Huang C, Jin X, Zheng C, Huang Y, Zheng X, Tian Z*, Sun H*. TIPE2 deletion improves the therapeutic potential of adoptively transferred NK cells. J Immunother Cancer. 2023 Feb;11(2):e006002. 6. Xiao X, Cheng Y, Zheng X, Fang Y, Zhang Y, Sun R, Tian Z* , Sun H* . Bispecific NK-cell engager targeting BCMA elicits stronger antitumor effects and produces less proinflammatory cytokines than T-cell engager. Front Immunol. 2023 Apr 11;14:1113303 7. Fang Y, Sun H, Xiao X, Tang M, Tian Z, Wei H, Sun R*, Zheng X*. Low-dose immunogenic chemotherapeutics promotes immune checkpoint blockade in microsatellite stability colon cancer. Front Immunol. 2022 Oct 27;13:1040256. 8. Zhang W, Sun Y, Sun R, Lian Z, Wei H, Tian Z*, Chen Y*. HBV immune tolerance of HBs-transgenic mice observed through parabiosis with WT mice. Front Immunol. 2022 Sep 20;13:993246. 9. Wu Y, Hao X, Wei H, Sun R*, Chen Y*, Tian Z*. Blockade of T-cell receptor with Ig and ITIM domains elicits potent antitumor immunity in naturally occurring HBV-related HCC in mice. Hepatology. 2023 Mar 1;77(3):965-981. 10. Wang D, Sun Z*, Zhu X*, Zheng X, Zhou Y, Lu Y, Yan P, Wang H, Liu H, Jin J, Zhu H, Sun R, Wang Y, Fu B, Tian Z, Wei H*.GARP-mediated active TGF-β1 induces bone marrow NK cell dysfunction in AML patients with early relapse post-allo-HSCT. Blood. 2022 Aug 18:blood.2022015474. 11. Zheng X*, Wu Y, Bi J, Huang Y, Cheng Y, Li Y, Wu Y, Cao G, Tian Z*. The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy. Cell Mol Immunol. 2022 Feb;19(2):192-209. doi: 10.1038/s41423-021-00786-6. 12. Chen Y#, Wang X#, Hao X, Li B, Tao W, Zhu S, Qu K, Wei H, Sun R, Peng H*, Tian Z*. Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions. J Exp Med. 2022 May 2;219(5):e20211805. 13. Jiao D, Zheng X*, Du X, Wang D, Hu Z, Sun R, Tian Z, Fu B*, Wei H*. Immunogenic senescence sensitizes lung cancer to LUNX-targeting therapy. Cancer Immunol Immunother. 2022 Jun;71(6):1403-1417. 14. Liu H, Zhao R, Qin R, Sun H, Huang Q, Liu L, Tian Z, Nashan B, Sun C*, Sun R*. Panoramic comparison between NK cells in healthy and cancerous liver through single-cell RNA sequencing. Cancer Biol Med. 2022 Jul 21;19(9):1334-1351 15. Zhou Y, Zhang J, Wang D, Wang D, Guan W, Qin J, Xu X, Fang J, Fu B, Zheng X, Wang D, Zhao H, Chen X, Tian Z, Xu X, Wang G, Wei H. Profiling of the immune repertoire in COVID-19 patients with mild, severe, convalescent, or retesting-positive status. J Autoimmun. 2021 Mar;118:102596. 16. Zhang J, Wu H, Yao X, Zhang D, Zhou Y, Fu B, Wang W, Li H, Wang Z, Hu Z, Ren Y, Sun R, Tian Z, Bian X, Wei H. Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm. Cell Mol Immunol. 2021 May;18(5):1305-1307. 17. Li Y, Zhang Y, Cao G, Zheng X, Sun C, Wei H, Tian Z, Xiao W, Sun R, Sun H. Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors. J Hematol Oncol. 2021 Jun 26;14(1):100. 18. Zhang C, Wang H, Li J, Hou X, Li L, Wang W, Shi Y, Li D, Li L, Zhao Z, Li L, Aji T, Lin R, Shao Y, Vuitton DA, Tian Z, Sun H, Wen H. Involvement of TIGIT in Natural Killer Cell Exhaustion and Immune Escape in Patients and Mouse Model With Liver Echinococcus multilocularis Infection. Hepatology. 2021 Dec;74(6):3376-3393. 19. Jin L, Sun Z*, Liu H, Zhu X, Zhou Y, Fu B, Zheng X, Song K, Tang B, Wu Y, Zhu J, Sun R, Tian Z*, Wei H*. Inflammatory monocytes promote pre-engraftment syndrome and tocilizumab can therapeutically limit pathology in patients. Nat Commun. 2021 Jul 6;12(1):4137. 20. Nian Z, Zheng X*, Dou Y, Du X, Zhou L, Fu B, Sun R, Tian Z, Wei H*. Rapamycin Pretreatment Rescues the Bone Marrow AML Cell Elimination Capacity of CAR-T Cells. Clin Cancer Res. 2021 Nov 1;27(21):6026-6038. 21. Cao G, Cheng Y, Zheng X, Wei H, Tian Z, Sun R*, Sun H*. All-trans retinoic acid induces leukemia resistance to NK cell cytotoxicity by down-regulating B7-H6 expression via c-Myc signaling. Cancer Commun (Lond). 2021 Jan;41(1):51-61. 22. Song J, Song H, Wei H, Sun R*, Tian Z*, Peng H*. Requirement of RORα for maintenance and antitumor immunity of liver-resident natural killer cells/ILC1s. Hepatology. 2022 May;75(5):1181-1193. 23. Bi J*, Cheng C, Zheng C, Huang C, Zheng X, Wan X, Chen YH, Tian Z, Sun H*. TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity. Sci Adv. 2021 Sep 17;7(38):eabi6515. 24. Song H, Song J, Cheng M, Zheng M, Wang T, Tian S, Flavell RA, Zhu S, Li HB, Ding C, Wei H, Sun R, Peng H*, Tian Z*. METTL3-mediated m<sup>6</sup>A RNA methylation promotes the anti-tumour immunity of natural killer cells. Nat Commun. 2021 Sep 17;12(1):5522. 25. Liu S, Liu J, Yang X, Jiang M, Wang Q, Zhang L, Ma Y, Shen Z, Tian Z, Cao X*. Cis-acting lnc-Cxcl2 restrains neutrophil-mediated lung inflammation by inhibiting epithelial cell CXCL2 expression in virus infection. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2108276118. 26. Jiao D, Zheng X, Du X, Wang D, Hu Z, Sun R, Tian Z, Fu B*, Wei H*. Immunogenic senescence sensitizes lung cancer to LUNX-targeting therapy. Cancer Immunol Immunother. 2022 Jun;71(6):1403-1417. 27. Shen C, Li R, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S*, Wu H*. Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome. Cell. 2021 Nov11;184(23):5759-5774.e20. 28. Wang D, Wang D, Huang M, Zheng X, Shen Y, Fu B, Zhao H, Chen X, Peng P, Zhu Q, Zhou Y, Zhang J, Tian Z, Guan W, Wang G, Wei H*. Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNA. J Mol Cell Biol. 2021 Dec 30;13(10):748-759. 29. Wang D, Fu B, Shen X, Guo C, Liu Y, Zhang J, Sun R, Ye Y, Li J, Tian Z*, Wei H*. Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy. Signal Transduct Target Ther. 2021 Nov 5;6(1):376. doi: 10.1038/s41392-021-00776-0. 30. Zhang H, Zhang Y, Pan J, Wu Q, Huang Y, Bai S, Tian C, Zhu M, Lian Z, Li F, Tian Z, Bai L*. iNKT subsets differ in their developmental and functional requirements on Foxo1. Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2105950118. 32. Chen M, Li Y, Wu Y, Xie S, Ma J, Yue J, Lv R, Tian Z, Fang F*, Xiao W*. Anti-Tumor Activity of Expanded PBMC-Derived NK Cells by Feeder-Free Protocol in Ovarian Cancer. Cancers (Basel). 2021 Nov 22;13(22):5866. 33. Bai L, Vienne M, Tang L, Kerdiles Y, Etiennot M, Escalière B, Galluso J, Wei H, Sun R, Vivier E, Peng H*, Tian Z*. Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop. Science. 2021 Mar 26;371(6536):eaba4177. 34. Hao X, Chen Y, Bai L, Wei H, Sun R*, Tian Z*. HBsAg-specific CD8+T cell as an indispensable trigger to induce murine hepatocellular carcinoma. Cell Mol Immunol. 2021 Jan;18(1):128-137. 35. Zhou Y#, Fu B#, Zheng X#, Wang D, Zhao C, qi Y, Sun R, Tian Z, Xu X*, Wei H*. Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients. Natl Sci Rev. 2020 Jun;7(6):998–1002. 36. Zhou Y, Fu B*, Xu X, Zhang J, Tong X, Wang Y, Dong Z, Zhang X, Shen N, Zhai Y, Kong X, Sun R, Tian Z*, Wei H*. PBX1 expression in uterine natural killer cells drives fetal growth. Sci Transl Med. 2020 Apr;12(537). 37. Zheng M#*, Gao Y#, Liu S, Sun D, Yang F, Zong L, Zhang M, Tian Z, Xu Y*, Sun H*. Serum inflammatory factors are positively correlated with the production of specific antibodies in coronavirus disease 2019 patients. Cell Mol Immunol. 2020 Nov;17(11):1180-1182. 38. Zheng M*, Gao Y, Wang G, Song G, Liu S, Sun D, Xu Y*, Tian Z*. Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell Mol Immunol. 2020 May;17:533–535. 39. Cheng Y, Zheng X, Wang X, Chen Y, Wei H, Sun R, Tian Z*, Sun H*. Trispecific killer engager 161519 enhances natural killer cell function and provides anti-tumor activity against CD19-positive cancers. Cancer Biol Med. 2020 Nov 15;17(4):1026-1038. 40. Fan Y, Zhang W, Wei H, Sun R, Tian Z*, Chen Y*. Hepatic NK cells attenuate fibrosis progression of non-alcoholic steatohepatitis in dependent of CXCL10-mediated recruitment. Liver Int. 2020 Mar;40(3):598-608. 41. Xu X， Zhou Y，Fu B，Zhang J, Dong Z, Zhang X, Shen N, Sun R, Tian Z*, Wei H*. PBX1 promotes development of natural killer cells by binding directly to the Nfil3 promoter. FASEB J. 2020 May;34(5):6479-6492. 42. Li W, Zhou J, Wang X, Wu Y, Ye L, Wei H, Sun R, Tian Z*, Peng H*. CD49a+CD49b+ NK cells induced by viral infection reflect an activated state of conventional NK cells. Sci China Life Sci. 2020 Nov;63(11):1725-1733. 43. Hu Z, Zheng X, Jiao D, Zhou Y, Sun R, Wang B*, Tian Z*, Wei H*. LunX-CAR T Cells as a Targeted Therapy for Non-Small Cell Lung Cancer. Mol Ther Oncolytics. 2020 Apr 21;17:361-370. 44. Wu Y, Wang J, Zheng X, Chen Y, Huang M, Huang Q, Xiao W, Wei H, Tian Z, Sun R*, Sun C*. Establishment and Preclinical Therapy of Patient-derived Hepatocellular Carcinoma Xenograft Model. Immunol Lett. 2020 Jul;223:33-43. 45. Wang D, Cong J, Fu B, Zheng X, Sun R, Tian Z, Wei H*. Immunogenic chemotherapy effectively inhibits KRAS-Driven lung cancer. Cancer Lett. 2020 Aug 3;492:31-43. 46. Li M, Li S, Zhou H, Tang X, Wu Y, Jiang W, Tian Z, Zhou X, Yang X, Wang Y. Chemotaxis-driven Delivery of Nano-Pathogenoids for Complete Eradication of Tumors Post-Phototherapy. Nat Commun. 2020 Feb 28;11(1):1126. 47. Fu S, He K, Tian C, Sun H, Zhu C, Bai S, Liu J, Wu Q, Xie D, Yue T, Shen Z, Dai Q, Yu X, Zhu S, Liu G, Zhou R, Duan S, Tian Z, Xu T, Wang H, Bai L. Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells. Nat Commun. 2020 Jan 23;11(1):438. 48. Zhao Z, Lu F, Ma H, Wang Y, Yang W, Long J, Miao Q, Zhang W, Tian Z, Ridgway W, Cao J*, Gershwin M*, Lian Z*. Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4+T cells. Cell Mol Immunol. 2020 Feb;17(2):178-189. 49. Li K#, Wu Y#, Li Y, Yu Q, Tian Z, Wei H*, Qu K*. Landscape and Dynamics of the Transcriptional Regulatory Network During Natural Killer Cell Differentiation. Genom Proteom Bioinf. 2020 Dec 29;S1672-0229(20)30166-2. 50. Zheng X, Qian Y, Fu B, Jiao D, Jiang Y, Chen P, Shen Y, Zhang H, Sun R, Tian Z*, Wei H*. Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance. Nat Immunol. 2019 Dec;20(12):1656-1667. 51. Bai L, Peng H*, Hao X, Tang L, Sun C, Zheng M, Liu F, Lian Z, Bai L, Wei H, Sun R*, Tian Z*.CD8+ T Cells Promote Maturation of Liver-Resident NK Cells via the CD70-CD27 axis. Hepatology. 2019 Nov;70(5):1804-1815. 52. Wang D, Zheng X, Fu B，Nian Z, Qian Y, Sun R, Tian Z*, Wei H*.Hepatectomy promotes recurrence of liver cancer by enhancing IL-11-STAT3 signaling. EBio Medicine. 2019 Aug;46:119-132. 53. Wang B, Zhou J, Chen Y, Wei H, Sun R, Tian Z*, Peng H*. A novel spleen-resident immature NK cell subset and its maturation in a T-bet-dependent manner. J Autoimmun. 2019 Jul 24:102307. 54. Sun H*, Liu L, Huang Q, Liu H, Huang M, Wang J, Wen H, Lin R, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z*, Sun C*. Accumulation of tumor-infiltrating CD49a+ NK cells correlates with poor prognosis for human hepatocellular carcinoma.Cancer Immunol Res. 2019 Sep;7(9):1535-1546. 55. Sun H, Huang Q, Huang M, Wen H, Lin R, Zheng M, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z*, Sun C* . Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma. Hepatology. 2019 Jul;70(1):168-183. 56. Chen Y*, Hao X, Sun R, Wei H, Tian Z*. NK cell-derived IFN-γ promotes hepatocellular carcinoma through EpCAM-EMT axis in hepatitis B virus transgenic mice. Hepatology. 2019 Apr;69(4):1735-1750. 57. Zhou J, Peng H*, Li K,Qu K, Wang B, Wu Y, Ye L, Dong Z, Wei H, Sun R, Tian Z*. Liver-resident NK cells control antiviral activity of hepatic T cells via PD-1/PD-L1 axis. Immunity. 2019 Feb 19;50(2):403-417. 58. Zong L, Peng H , Sun C, Li F, Zheng M, Chen Y, Wei H, Sun R, Tian Z*.Breakdown of adaptiveimmunotolerance induces hepatocellular carcinoma in HBsAg-tg mice. Nat Commun. 2019 Jan 15;10(1):221.
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