彭慧教授

生命科学学院

电子邮箱

瀚海星云BBS

CMI杂志

中国科学技术大学

首页教授风采教授风采

彭慧教授

( 2020-05-26 )

彭慧 特任教授，博导，基金委优青获得者，2014年加入免疫所。2006和2012年毕业于中国科学技术大学，分别获学士和博士学位；2012至2014年在中科大免疫所从事博士后研究； 2019年获国家自然科学二等奖。主要研究成果发表于Immunity、Nature Commun、J Clin Invest、Trends Immunol等期刊。2015年入选第一届中国科协青年人才托举工程，获第五届中国免疫学会青年学者奖。

主要研究兴趣：NK细胞和固有淋巴细胞发育分化；NK细胞亚群在感染及肿瘤等重大疾病中的作用。

发表论文情况：

1.Chen Y#, Wang X#, Hao X, Li B, Tao W, Zhu S, Qu K, Wei H, Sun R, Peng H*, Tian Z*. Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions.J Exp Med. 2022 May 2;219(5):e20211805.

2.Song J#, Song H#, Wei H, Sun R*, Tian Z*, Peng H*. Requirement of RORα for maintenance and antitumor immunity of liver-resident natural killer cells/ILC1s. Hepatology. 2021 Sep 12. doi: 10.1002/hep.32147.

3.Song H, Song J, Cheng M, Zheng M, Wang T, Tian S, Flavell RA, Zhu S, Li HB, Ding C, Wei H, Sun R, Peng H*, Tian Z*. METTL3-mediated m<sup>6</sup>A RNA methylation promotes the anti-tumour immunity of natural killer cells. Nat Commun. 2021 Sep 17;12(1):5522.

4.Bai L, Vienne M, Tang L, Kerdiles Y, Etiennot M, Escalière B, Galluso J, Wei H, Sun R, Vivier E, Peng H*, Tian Z*. Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop. Science. 2021 Mar 26;371(6536):eaba4177.

5.Zhou J, Tian Z*, Peng H*. Tissue-resident NK cells and other innate lymphoid cells. Adv Immunol. 2020;145:37-53.

6.Chen Y, Tian Z, Peng H*.Immunological memory: ILC1s come into view.Cell Mol Immunol. 2019 Dec;16(12):895-896.

7.Wang B, Zhou J, Chen Y, Wei H, Sun R, Tian Z*, Peng H*.A novel spleen-resident immature NK cell subset and its maturation in a T-bet-dependent manner.J Autoimmun. 2019 Dec;105:102307.

8.Wang X,Tian Z*, Peng H*.Tissue-resident memory-like ILCs: innate counterparts of TRM cells.Protein Cell. 2020 Feb;11(2):85-96.

9.Bai L, Peng H*, Hao X, Tang L, Sun C, Zheng M, Liu F, Lian Z, Bai L, Wei H, Sun R*, Tian Z*.CD8+ T Cells Promote Maturation of Liver-Resident NK Cells via the CD70-CD27 axis.Hepatology. 2019 Nov;70(5):1804-1815.

10.Wang X, Peng H, Tian Z*.Innate lymphoid cell memory.Cell Mol Immunol. 2019 May;16(5):423-429.

11.Zhou J, Peng H*, Li K, Qu K, Wang B, Wu Y, Ye L, Dong Z, Wei H, SunR, Tian Z*. Liver-resident NK cells control antiviral activity of hepatic T cells via PD-1/PD-L1 axis.Immunity. 2019 Feb 19;50(2):403-417.

12.Zong L, Peng H*, Sun C, Li F, Zheng M, Chen Y, Wei H, Sun R, Tian Z*. Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice.Nat Commun. 2019 Jan 15;10(1):221.

13.Wang X, Peng H*, Cong J, Wang X, Lian Z, Wei H, Sun R, Tian Z*. Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis.Nat Commun. 2018 Nov 19;9(1):4854.

14.Peng H*, Tian Z*. NK cells in liver homeostasis and viral hepatitis. Sci China Life Sci. 2018 Dec;61(12):1477-1485.

15.Zhang Q, Bi J, Zheng X, Chen Y, Wang H, Wu W, Wang Z, Wu Q, Peng H, Wei H, Sun R, Tian Z*. Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nat Immunol. 2018 Jul;19(7):723-732.

16.Peng H*, Sun R*. Liver-resident NK cells and their potential functions.Cell Mol Immunol. 2017;14: 890–894.

17.Peng H*, Tian Z*. Natural Killer Cell Memory: Progress and Implications. Front Immunol. 2017 Sep 13;8:1143.

18.Peng H*, Tian Z*. Diversity of tissue-resident NK cells. Semin Immunol. 2017 Jun;31:3-10.

19.He Y, Peng H, Sun R, Wei H, Ljunggren HG, Yokoyama WM, Tian Z*.Contribution of inhibitory receptor TIGIT to NK cell education.J Autoimmun. 2017 Jul;81:1-12.

16.Peng H*, Tian Z. Tissue-resident natural killer cells in the livers. Sci China Life Sci. 2016 Dec;59(12):1218-1223.

20.Peng H, Wisse E*, Tian Z*.Liver natural killer cells: subsets and roles in liver immunity. Cell Mol Immunol. 2016 May;13(3):328-36.

21.Tang L, Peng H*, Zhou J, Chen Y, Wei H, Sun R, Yokoyama WM, Tian Z*. Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s.J Autoimmun. 2016 Feb;67:29-35.

22.Peng H, Tian Z*.Re-examining the origin and function of liver-resident NK cells.Trends Immunol. 2015 May;36(5):293-9.

23.Yokoyama WM*, Sojka DK, Peng H, Tian Z.Cold Spring Harb Symp Quant Biol. 2013;78:149-56.

24.Peng H, Tian Z*. NK cell trafficking in health and autoimmunity:a comprehensivereview. Clin Rev Allergy Immunol. 2014 Oct;47(2):119-27.

25.Chen Y, Peng H, Chen Y, Wei H, Sun R, Tian Z*. CD49a promotes T-cell-mediated hepatitis by driving T helper 1 cytokine and interleukin-17 production. Immunology. 2014 Mar;141(3):388-400.

26.Jiang X, Chen Y, Peng H, Tian Z*. Memory NK cells: why do they reside in the liver? Cell Mol Immunol. 2013 May;10(3): 196-201.

27.Peng H#, Jiang X#, Chen Y#, Sojka DK, Wei H, Gao X, Sun R, Yokoyama WM, Tian Z*.Liver-resident NK cells confer adaptive immunity in skin-contact inflammation. J Clin Invest. 2013 Apr;123(4):1444-56.

28.Peng H, Sun R, Tang L, Wei H, Tian Z*. CD62L is critical for maturation andaccumulation of murine hepatic NK cells in response to viral infection. JImmunol. 2013 Apr 15;190(8):4255-62.

29.Jiang X, Chen Y, Peng H, Tian Z*. Single line or parallel lines: NK cell differentiation driven by T-bet and Eomes. Cell Mol Immunol. 2012 May;9(3):193-4.