肖卫华教授

生命科学学院

电子邮箱

瀚海星云BBS

CMI杂志

中国科学技术大学

首页教授风采教授风采

肖卫华教授

( 2020-05-26 )

实验室网站：http://lstt.ustc.edu.cn

肖卫华 教授，博导，2004年进入免疫所。生命学院医药生物技术系常务副主任，附属第一医院肿瘤免疫治疗研究中心副主任，曾任中国抗癌协会生物治疗专委会副主任。白求恩医科大学医学学士；美国霍普金斯大学理学硕士；吉林大学医学博士。1995-1997年美国马里兰大学肿瘤研究中心；1997-2004年美国国立卫生研究院肿瘤研究所；主要研究成果发表于Nat Med、PNAS、Cancer Res和J Immunol等杂志。获授权专利13项，应用开发成果获2015年第四届全国创新创业医药组第三名。

主要研究兴趣：肿瘤免疫治疗技术及其应用。

主要代表文章：

1. Yangyang Li, Siqi Xie, Minhua Chen, Hao Li, Yehai Wang, Yan Fan, Kang An, Yu Wu and Weihua Xiao. Development of an antibody-ligand fusion protein scFvCD16A-sc4-1BBL in Komagataella phaffii with stimulatory activity for Natural Killer cells. Microb Cell Fact. 22, 67 (2023).

2. Fang F, Xie S, Chen M, Li Y, Yue J, Ma J, Shu X, He Y, Xiao W, Tian Z. Advances in NK cell production. Cell Mol Immunol. 2022 Apr;19(4):460-481.

3. Chen, M.; Li, Y.; Wu, Y.; Xie, S.; Ma, J.; Yue, J.; Lv, R.; Tian, Z.; Fang, F.; Xiao, W. Anti-Tumor Activity of Expanded PBMC-Derived NK Cells by Feeder-Free Protocol in Ovarian Cancer. Cancers. 2021, 13, 5866.

4. Huan Xu, Mingyang Shi, Changsheng Shao, Hao Li, Jing Wu, Yin Yu, Fang Fang, Yugang Guo, Weihua Xiao. Development of IL-15/IL-15Rα sushi domain-IgG4 Fc complexes in Pichia pastoris with potent activities and prolonged half-lives. Microb Cell Fact. 20, 115 (2021).

5. Miao Y, Jiang M, Qi L, Yang, Xiao W, Fang F. BCAP Regulates Dendritic Cell Maturation Through the Dual-Regulation of NF-κB and PI3K/AKT Signaling During Infection. Front Immunol. 2020 Feb 18;11:250.

6. Huimin Liu, Siqi Xie, Fang Fang, Dhananjaya V. Kalvakolanu and Weihua Xiao. SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response. Cell Death Dis. 11, 445 (2020).

7. Lu Qi , Qiuyan Zhang, Yuhui Miao, Wenyao Kang, Zhigang Tian, Damo Xu, Weihua Xiao, Fang Fang. Interleukin-33 Activates and Recruits Natural Killer Cells to Inhibit Pulmonary Metastatic Cancer Development. Int J Cancer. 2019 Mar 1;146(5):1421-1434

8. Zhou Y, Liu H, Wang J, Wang X, Qian L, Xu F, Song W, Wu D, Shen Z, Feng D, Ling B, Xiao W, Shan G, Chen L. ΔNp63α exerts antitumor functions in cervical squamous cell carcinoma. Oncogene. 2019 Oct 1. doi: 10.1038/s41388-019-1033-x. 4. Sun H, Liu L, Huang Q, Liu H, Huang M, Wang J, Wen H, Lin R, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z, Sun C. Accumulation of Tumor-Infiltrating CD49a(+) NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma. Cancer Immunol Res. 2019 Sep;7(9):1535-1546.

9. Song W, Wang J, Liu H, Zhu C, Xu F, Qian L, Shen Z, Zhu J, Yin S, Qin J, Chen L, Wu D, Nashan B, Shan G, Xiao W, Zhou Y. Effects of LncRNA Lnc-LIF-AS on cell proliferation, migration and invasion in a human cervical cancer cell line. Cytokine. 2019 Aug;120:165-175.

10. Sun H, Sun C, Xiao W, Sun R. Tissue-resident lymphocytes: from adaptive to innate immunity. Cell Mol Immunol. 2019 Jan 11. 7. Sun H, Huang Q, Huang M, Wen H, Lin R, Zheng M, Qu K, Li K, Wei H, Xiao W, Sun. R, Tian Z, Sun C. Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma. Hepatology. 2018 Nov 8.

11. Sun H, Xu J, Huang Q, Huang M, Li K, Qu K, Wen H, Lin R, Zheng M, Wei H, Xiao W, Sun R, Tian Z, Sun C. Reduced CD160 Expression Contributes to Impaired NK-cell Function and Poor Clinical Outcomes in Patients with HCC. Cancer Res. 2018 Dec 1;78(23):6581-6593.

12. Fang F, Xiao W, Tian Z. Challenges of NK cell-based immunotherapy in the new era. Front Med. 2018 Aug;12(4):440-450.

13. Fang F, Xiao W, Tian Z. NK cell-based immunotherapy for cancer. Semin Immunol. 2017 Jun;31:37-54.