金腾川研究员

生命科学学院

电子邮箱

瀚海星云BBS

CMI杂志

中国科学技术大学

首页教授风采

金腾川研究员

( 2020-05-27 )

实验室网站：http://tjlab.ustc.edu.cn/

金腾川 特任研究员，博导，2015年加入免疫所。2003年毕业于中国科学技术大学，获生物学理学学士和工商管理学士学位；2008年于美国伊利诺伊理工大学获分子生物化学和生物物理学博士学位；2008至2014年先后在美国国立卫生研究院，国立过敏及传染病研究所任Postdoc Fellow和Research Fellow；在Immunity、J Exp Med、Nucleic Acids Res、J Biol Chem、J Agric Food Chem等发表论文60余篇。

主要研究兴趣：固有免疫系统的结构生物学；炎症和自身免疫病的分子机制；蛋白质工程和蛋白质药物。

近期发表文章：

1.Samad A, Li Y, Zhang C, Chen F, Zeng W, Fan X, Jin T^*(2019). X-ray crystal structure of putative transcription regulator lmo2088 from Listeria monocytogenes. BiochemBiophys Res Communpii: S0006-291X(19)31922-9.

2.Zahid A, Li B, Kombe AJK, Jin T^*, Tao J^* (2019). Pharmacological Inhibitors of the NLRP3 Inflammasome. Front Immunol. 10:2538

3.Zeng W, Ma H, Fan W, Yang Y, Zhang C, Arnaud KombeKombe J, Fan X, Zhang Y, Dong Z, Shen Z, Zhou Y, Yang M^*, Jin T^*(2019). Structure determination of CAMP factor of Mobiluncus curtisii and insights into structural dynamics. Int J BiolMacromol. pii: S0141-8130

4.Chen F, Ma H, Li Y, Wang H, Samad A, Zhou J, Zhu L, Zhang Y, He J, Fan X^*, Jin T^*(2019). Screening of Nanobody Specific for Peanut Major Allergen Ara h 3 by Phage Display. J Agric Food Chem67(40):11219-11229.

5.Li W, Ji Q, Wei Z, Chen YL, Zhang Z, Yin X, Aghmiuni SK, Liu M, Chen W, Shi L, Chen Q, Du X, Yu L, Cao MJ, Wang Z, Huang S, Jin T^*, Wang Q^*(2019). Biochemical characterization of G64W mutant of acidic beta-crystallin 4. Exp Eye Res 186:107712.

6.Li Y, Zeng W, Li Y, Fan W, Ma H, Fan X, Jiang J, Brefo-Mensah E, Zhang Y, Yang M, Dong Z, Palmer M, Jin T^*(2019). Structure determination of the CAMP factor of Streptococcus agalactiae with the aid of an MBP tag and insights into membrane-surface attachment. ActaCryst D 75(Pt 8):772-781.

7.Yin X, Li W, Ma H, Zeng W, Li Y, Liu M, Chen Q, Zhou R, Jin T^*(2019). Crystal structure and activation mechanism of DR3 death domain. FEBS J286(13):2593-2610.

8.Jin T*^,^＃, Brefo. E^＃, Fan W, Zeng W, Li Y, Zhang YZ, Palmer M (2018). Crystal structure of the Streptococcus agalactiae CAMP factor provides insights into its membrane-permeabilizing activity. J BiolChem293(30):11867-11877.

9.Li Y, Huang Y, Cao X, Yin X, Jin X, Liu S, Jiang J, Jiang W, Xiao TS, Zhou R, Cai G, Hu B, Jin T* (2018). Functional and Structural Characterization of Zebrafish ASC. FEBS J 285(14):2691-2707.

10.Fang K, Li Y, Yin X, Samad A, Jin T* (2018).High-Level Prokaryotic Expression and Purification of Death Domain Superfamily with MBP Tag.Clin Lab. 64(4):467-475.

11.Zhou K, Fan X, Li Y, Zhang C, Jin T* (2018). High-resolution crystal structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase.ActaCrystallogr F StructBiolCommun 74(Pt 4):236-244.

12.Jin T*, Huang M, Jiang J, Smith P, Xiao TS* (2018). Crystal structure of human NLRP12 PYD domain and implication in homotypic interaction. PLoS One 13(1): e0190547.

13.Jin T*, Wang C, Zhang CY, Wang Y, Chen YW, Guo F, Howard A, Cao MJ, Fu TJ, McHugh TH, Zhang YZ* (2017). Crystal Structure of Cocosin, A Potential Food Allergen from Coconut  (Cocos nucifera). J Agric Food Chem65(34): 7560-7568.

14.Jin T*, Chuenchor W, Jiang J, Cheng J, Li YJ, Fang K, Huang M, Smith P, Xiao TS* (2017). Design of an expression system to enhance MBP-mediated crystallization. Sci Rep 7:40991-40997.

15.Cao X^#, Li YJ^#*, Jin X, Li YL, Guo F, Jin T* (2017). Molecular Mechanism of Divalent-Metal-Induced Activation of NS3 Helicase and Insights into Zika Virus Inhibitor Design. Nucleic Acids Res 44(21): 10505-10514.

16.Zhang C, Feng T, Cheng J, Li YJ, Yin X, Zeng W, Jin X, Li YL, Guo F and Jin T*(2017). Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design. BiochemBiophs Res Commun492(4):624-630.

17.Li YJ, Li YL, Cao X, Jin X, and Jin T* (2017). Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways. Cell MolImmunol14(1):80-89.