中国科学技术大学生命科学学院免疫学研究所
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曾筑天 研究员
( 2020-05-27 )

 


    实验室网站:http://staff.ustc.edu.cn/~zengzt/

曾筑天 特任研究员,博导,2019年加入免疫所。2008和2014毕业于中国科学技术大学,分别获得理学学士和博士学位;2014至2019年于加拿大卡尔加里大学从事博士后研究,期间获得博士生国家奖学金、AIHS博士后奖学金等资助。主要研究成果发表于Nat Immunol、Cell Host & Microbe、J Exp Med和J Immunol等期刊。

 

主要研究兴趣:活体显微成像与动态免疫学;感染、炎症、肿瘤、损伤修复等动态可视化免疫学研究。

发表论文情况:

  1. Liu W, Zhou X, Yao Q, Chen C, Zhang Q, Ding K, Li L, Zeng Z.In Situ Expansion and Reprogramming of Kupffer Cells Elicits Potent Tumoricidal Immunity against Liver Metastasis. J Clin Invest. 2023 Feb 23:e157937. 

  2.  Li L, Zeng Z.Live Imaging of Innate and Adaptive Immune Responses in the Liver.  Front Immunol. 2020 Sep 17; 11:564768.

  3. Zeng Z, Surwarrd BG,Wong CH, Guettler C, Petri B, Burkhard R, Wyss M, Moual HL, Devinney R, Thompson GC, Blackwood J, Joffe AR,  McCoy KD, Jenne CN, Kubes P. Sex-hormone-driven innate antibodies protect females and infants against EPEC infection. Nature Immunology.2018; 19: 1100-1111.

  4. Zeng Z, Surwarrd BG,Wong CH, Geoghegan AJ, Jenne CN, Kubes P. CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria. Cell Host&Microbe. 2016; 20 (1):99-106.

  5. Zeng Z, Li L, Chen Y, Wei H, Sun R, Tian Z. Interferon-gamma Facilitates Hepatic Antiviral T cell Retention for the Maintenance of Liver-induced Systemic Tolerance. J Exp Med. 2016; 213(6):1079-93.

  6. Zeng Z, Kong X, Li F, Wei H, Sun R, Tian Z. IL-12-based vaccination therapy reverses liver-induced systemic tolerance in a mouse model of hepatitis B virus carrier. Journal of immunology 2013, 191(8): 4184-4193.

  7. An H, Qian C, Huang Y, Li J, Tian X, Feng J, Hu J, Fang Y, Jiao F, Zeng Y, Huang X, Meng X, Liu X, Lin X, Zeng Z, Guilliams M, Beschin A,et al.Functional Vulnerability of Liver Macrophages to Capsules Defines Virulence of Blood-borne Bacteria.J Exp Med. 2022 Apr 4;219(4):e20212032.

  8.  Zhou H,  Zeng Z, Wang F.Intravital Microscopy Imaging of Invariant Natural Killer T-Cell Dynamics in the Liver Using CXCR6-eGFP Transgenic Mice. Methods Mol Biol. 2021;2388:149-156.

  9. Pose E, Coll M, Martínez-Sánchez C, Zeng Z, Surewaard BGJ, Català C, Velasco-de Andrés M, Lozano JJ, Ariño S, Fuster D, Niñerola-Bazán A, Graupera I, Muñoz É, Lozano F, Sancho-Bru P, Kubes P, Ginès P.Programmed Death Ligand 1 Is Overexpressed in Liver Macrophages in Chronic Liver Diseases, and Its Blockade Improves the Antibacterial Activity Against Infections. Hepatology. 2021 Jul;74(1):296-311.

  10. Guo C, Cai P, Jin L, Sha Q, Yu Q, Zhang W, Jiang C, Liu Q, Zong D, Li K, Fang J, Lu F, Wang Y, Li D, Lin J, Li L, Zeng Z, Tong X, Wei H, Qu K.Single-cell Profiling of the Human Decidual Immune Microenvironment in Patients with Recurrent Pregnancy Loss. Cell Discov. 2021 Jan 4;7(1):1. 

  11. Li S, Li M, Huo S, Wang Q, Chen J, Ding S, Zeng Z, Zhou W, Wang Y, Wang J.Voluntary-Opsonization-Enabled Precision Nanomedicines for Inflammation Treatment.Adv Mater. 2021 Jan;33(3):e2006160.

  12. Hilscher MB, Sehrawat T, Arab Verdugo JP, Zeng Z, Gao J, Liu M, et al. Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension. Gastroenterology 2019, 157:193-209.

  13. Thanabalasuriar A, Scott BNV, Peiseler M, Willson ME, Zeng Z, Warrener P, Keller AE, et al., Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion. Cell host & microbe 2019, 25(4):526-536.

  14. Naumenko V, Van S, Dastidar H, Kim DS, Kim SJ, Zeng Z, et al. Visualizing Oncolytic Virus-Host Interactions in Live Mice Using Intravital Microscopy. Molecular therapy oncolytics 2018, 10: 14-27.

  15. Surewaard BGJ, Thanabalasuriar A, Zeng Z, Tkaczyk C, Cohen TS, Bardoel BW, et al. α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis. Cell host & microbe 2018, 24(2): 271-284 e273.

  16. Kasturirangan S, Rainey GJ, Xu L, Wang X, Portnoff A, Chen TZ, Fazenbaker C, Zhong H, Bee J, Zeng Z. et al. Targeted Fcgamma Receptor (FcgammaR)-mediated Clearance by a Biparatopic Bispecific Antibody. The Journal of biological chemistry 2017, 292(10): 4361-4370.

  17. Li L, Zeng Z, Qi Z, Wang X, Gao X, Wei H, Sun R, Tian Z.Natural Killer Cells-Produced IFN-γ Improves Bone Marrow-Derived Hepatocytes Regeneration in Murine Liver Failure Model. Sci Rep. 2015 Sep 8;5:13687.

  18. Dal-Secco D, Wang J, Zeng Z, Kolaczkowska E, Wong CH, Petri B, et al. A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury. J Exp Med 2015, 212(4): 447-456.


 

 

 


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