李博峰研究员

生命科学学院

电子邮箱

瀚海星云BBS

CMI杂志

中国科学技术大学

首页教授风采教授风采

李博峰研究员

( 2020-05-27 )

实验室网站：http://biomed.ustc.edu.cn/2019/0712/c17746a388956/page.htm

李博峰 特任研究员，博导，2019年加入免疫所。2001年毕业于厦门大学生命科学学院，获生物学学士学位；2006年毕业于中国科学技术大学生命科学院，获细胞生物学博士学位；先后在美国芝加哥大学病理系（2006-2009）和美国St.jude儿童研究医院病理系（2009-2018）从事博士后研究；主要研究成果发表于Hepatology 、Nat Commun等期刊，他引500余次。2006年获中国科学院院长优秀奖。

主要研究兴趣：细胞因子信号转导与自身免疫疾病调控机制；肿瘤免疫治疗及其新靶点发现。

发表SCI论文情况：

1. Gong F, Wei HX, Qi J, Ma H, Liu L, Weng J, Zheng X, Li Q, Zhao D, Fang H, Liu L, He H, Ma C, Han J, Sun A, Wang B, Jin T*, Li B*, Bofeng Li*. “Pulling-Force Spinning Top for Serum Separation Combined with Paper-Based Microfluidic Devices in COVID-19 ELISA Diagnosis.“ ACS Sensors. 2021, 6:2709-2719.

2. Gong F, Wei HX, Li Q, Liu L, Bofeng Li*. “Evaluation and Comparison of Serological Methods for COVID-19 Diagnosis.” Front Mol Biosci, 2021, 8:682405.

3. Xu Z, Zhou Y, Liu M, Ma H, Sun L, Zahid A, Chen Y, Zhou R, Cao M, Wu D, Zhao W，Bofeng Li*, Jin T*. “Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome.” Cell Death Dis. 2021;12:57.

4. Wei HX, Wang B, Bofeng Li*. “IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology. Front Immunol. 2020 ;11:1315.

5. Zahid A, Ismail H, Bofeng Li*, Jin T*. “Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity. Front Immunol. 2020 ;11:613039.

6. Koelink PJ , Bloemendaal FM, Bofeng Li, Westera L, Vogels EM, van RM, Gloudemans AK, van 't Wout AB, Korf H, Vermeire S, Velde AA, Ponsioen CY, D'Haens GR, Verbeek JS, Geiger TL, Wildenberg ME, van den Brink GR. “Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling.” Gut. 2020 69:1053-1063.

7. Wei H, Sun A, Bofeng Li, Guo F. Interleukin10 Family Cytokines Immunobiology and Structure. Adv Exp Med Biol. 2019;1172:79-96.

8. Zahid A Bofeng Li, Kombe AJK, Jin T, Tao J. Pharmacological Inhibitors of the NLRP3 Inflammasome. Front Immunol. 2019;10:2538.

9. Bofeng Li, Jones LL, Geiger TL. “IL-6 Promotes T Cell Proliferation and Expansion under Inflammatory Conditions in Association with Low-Level RORgammat Expression.”Journal of Immunology. 2018. 201:2934-2946.

10 Jones LL, Alli R, Bofeng Li, Geiger TL.“Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.”Journal of Immunology. 2016. 196:2973-2985.

11. Zhao Y, Nguyen P, Vogel P, Bofeng Li, Jones LL, Geiger TL. “Autoimmune susceptibility imposed by public TCRβ chains.” Scientific Reports. 2016. 21:37543.

12. Bofeng Li, Gurung P, Malireddi RK, Vogel P, Kanneganti TD, Geiger TL.“IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis.” Nature Communications. 2015. 6:6131.

13. Gurung P, Bofeng Li, Malireddi RK, Lamkanfi M, Geiger TL, Kanneganti TD.“Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation.” Scientific Reports. 2015. 5:14488.

14. B Bofeng Li, Alli R, Vogel P, Geiger TL.“IL-10 modulates DSS-induced colitis through a macrophage-ROS-NO axis.”Mucosal Immunology. 2014. 7:869-878.

15. Tauro S, Nguyen P, Bofeng Li, Geiger TL.“Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis.”European Journal of Immunology. 2013. 43:1195-1207.

16. Savage AK, Constantinides MG, Han J, Picard D, Martin E, Bofeng Li, Lantz O, Bendelac A.“The transcription factor PLZF directs the effector program of the NKT cell lineage.”Immunity. 2008. 29:391-403.

17. Wei HX, Chuang YH, Bofeng Li, Wei H, Sun R, Moritoki Y, Gershwin EM, Lian ZX, Tian Z.“CD4+CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice.”Journal of Immunology. 2008. 181:7221-7229.

18. Bofeng Li, Sun R, Wei H, Gao B, Tian Z.“Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism.” Hepatology. 2006. 43:1211-1219.