潘文教授

生命科学学院

电子邮箱

瀚海星云BBS

CMI杂志

中国科学技术大学

首页教授风采教授风采

潘文教授

( 2020-05-27 )

潘文特任教授，博导，2018年加入免疫所。2006年毕业于南京大学，获学士学位；2012年毕业于上海生命科学研究院，获博士学位；2013至2018年于耶鲁大学从事博士后研究，期间获得美国LLS基金会Fellow Award；主要研究成果分别发表在Immunity、Nat Med、Nat Commun以及J Immunol等期刊上，多次被Nat Rev Immunol、Nat Med、Nat Immunol点评以及被Faculty 1000收录和推荐。

主要研究兴趣：TAM与肿瘤免疫逃逸新机制及其免疫治疗新策略。

近期发表文章：

1. M. Lv, D. Cao, L. Zhang, C. Hu, S. Li, P. Zhang, L. Zhu, X. Yi, C. Li, A. Yang, Z. Yang, Y. Zhu, K. Zhang, Pan, W*. METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth. 2021. Protein & Cell.

2. Pan, W., K. Qu, S. Zhu, K. Meeth, J. Cheng, H. Ma, Y. Liao, X. Wen, C. Roden, Z. Tobiasova, Z. Wei, J. Zhao, J. Liu, J. Zheng, B. Guo, M. Bosenberg, R.Flavell, J. Lu.The DNA methylcytosine dioxygenaseTet2 sustains immunosuppressive function of tumor-infiltrating myeloid cells to promote melanoma progression.

Immunity. 2017. 47:284-297.

3. Zhu. S, S. Ding, P. Wang, Z. Wei, W. Pan, N. Palm, Y. Yang, H. Yu, H. Li, G. Wang, X. Lei, M. Zoete, J. Zhao, Y. Zheng, H. Chen, Y. Zhao, K. Jurado, N. Feng, L. Shan, Y. Kluger, J. Lu, C. Abraham, E. Fikrig, H. Greenberg, R. Flavell. Nlrp9b inflammasome recognizes and restricts enteric viral infection in intestinal epithelial cells. Nature. 2017. 546(7660):667-670

4. J Liu, B Guo, Z Chen, N Wang, M Iacovino, J Cheng, C Roden, W Pan, S. Khan, S. Chen, M. Kyba, R. Fan, S. Guo, Jun Lu. miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. Blood. 2017.

5. C Roden, J Gaillard, S Kanoria, W Rennie, S Barish, J Cheng, W Pan, J. Liu, C. Cotsapas, Y. Ding, J. Lu. Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation. Genome research (2017) 27 (3), 374-384.

6. J. Cheng, C. Roden, W. Pan, S. Zhu, A. Baccei, X. Pan, T. Jiang, Y. Kluger, S. Weissman, S. Guo, R.Flavell, Y. Ding, J. Lu. A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions. Nature Communications. (2016) March 30; 7:11178.

7. Pan,W., D. Dai, S.Zhu, Z.Liu, D. Li, B.Li, Y.Tang, N. Gagliani, M. Weirauch, X. Chen, W. Zhu, Y. Qian, L.Richman, B. Jallal, J.B. Harley, R.Flavell, Y.Yao and N.Shen. MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis. Nature Communications. (2015) May 12.6:7096.

8. P.Wang, S.Zhu, L. Yang, S.Cui, W.Pan, R.Jackson, Y.Zheng, A.Rongvaux, LongYang, Q.Sun, G. Yang, S. Gao, R. Lin, F. You, R. Flavell, E. Fikrig. Nlrp6 regulates intestinal antiviral innate immunity. Science. 2015.

9. Jijun Cheng, Shangqin Guo, Suning Chen, Stephen J.Mastriano, Chaochun Liu, Ana C. D’Alessio, Eriona Hysolli, Yanwen Guo, HongYao, Cynthia M.Megyola, DanLi, JunLiu, WenPan, Christine Roden, XiaoLingZhou, Kartoosh Heydari, Jianjun Chen, In-Hyun Park,Ye Ding, Yi Zhang, Jun Lu. An extensive network of TET2-targeting microRNAs regulates malignant hematopoiesis. Cell Reports.2013.5:471-481.

10. Zhu,S., W.Pan, Y. Qian. 2013. MicroRNA in immunity and autoimmunity. J Mol Med. 91:1039-50.

11. Zhu,S.*, W.Pan*, X. Song, Y. Liu, Y. Tang, H. Wang, W. Liu, Y. Shi, D. He, J.B. Harley, N. Shen and Y.Qian. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKKα. Nature Medicine. 2012. 18 (7), 1077-1086 (*co-first author)

12. JiaLi, QiongFu, Huijuan Cui, Bo Qu, WenPan, NanShen, and Chunde Bao. Interferon alpha priming promotes lipid uptake and macrophage-derived foam cell formation. Arthritis & Rheumatism.2011.63:492.

13. Pan,W., S.Zhu, M.Yuan, H.Cui, L.Wang, X.Luo, J.Li, H.Zhou, Y.Tang and N.Shen. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase1.2010. J Immunol.184:6773-6781.

14. Zhu,S., W.Pan, P. Shi, H. Gao, F. Zhao, X. Song, Y. Liu, L. Zhao, X. Li, Y. Shi, and Y. Qian. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. 2010. J Exp Med. 207:2647-2662.