孙汭教授

生命科学学院

电子邮箱

瀚海星云BBS

CMI杂志

中国科学技术大学

首页教授风采教授风采

孙汭教授

( 2020-05-27 )

实验室网站：http://ioi.ustc.edu.cn/sr_lab

孙汭教授、博士生导师。2006年进入免疫所。享受国务院政府特殊津贴。中国免疫学会感染免疫分会副主任委员，中国免疫学会女科学家工作委员会副主任委员。1995-1996和2001-2006先后在美国国立卫生研究院（NIH）癌症研究所（NCI）和酒精性疾病研究所（NIAAA）进行天然免疫学的合作研究。1994年获第四届“中国青年科技奖”，2005年获NIH杰出研究员奖。在Nat Immunol、Immunity、Hepatology、J Immunol等杂志发表SCI论文160余篇。

主要研究兴趣：NK细胞生物学研究；肝脏天然免疫学研究；免疫生物治疗及其相关产品研究。

主要代表论文：

1. Wu Y, Hao X, Wei H, Sun R*, Chen Y*, Tian Z*. Blockade of T-cell receptor with Ig and ITIM domains elicits potent antitumor immunity in naturally occurring HBV-related HCC in mice. Hepatology. 2023 Mar 1;77(3):965-981.

2. Fang Y, Sun H, Xiao X, Tang M, Tian Z, Wei H, Sun R*, Zheng X*. Low-dose immunogenic chemotherapeutics promotes immune checkpoint blockade in microsatellite stability colon cancer. Front Immunol. 2022 Oct 27;13:1040256.

3. Chen Y#, Wang X#, Hao X, Li B, Tao W, Zhu S, Qu K, Wei H, Sun R, Peng H*, Tian Z*. Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions. J Exp Med. 2022 May 2;219(5):e20211805.

4. Liu H, Zhao R, Qin R, Sun H, Huang Q, Liu L, Tian Z, Nashan B, Sun C*, Sun R*. Panoramic comparison between NK cells in healthy and cancerous liver through single-cell RNA sequencing. Cancer Biol Med. 2022 Jul 21;19(9):1334-1351

5. Bai L#, Vienne M#, Tang L#, Kerdiles Y#, Etiennot M, Escalière B, Galluso J, Wei H, Sun R*, Vivier E*, Peng H*, Tian Z*.Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop. Science. 2021 Mar 26;371(6536):eaba4177.

6. Li Y, Zhang Y, Cao G, Zheng X, Sun C, Wei H, Tian Z, Xiao W, Sun R*, Sun H*. Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors. J Hematol Oncol. 2021 Jun 26;14(1):100.

7. Song J#, Song H#, Wei H, Sun R*, Tian Z*, Peng H*. Requirement of RORα for maintenance and antitumor immunity of liver-resident natural killer cells/ILC1s. Hepatology. 2022 May;75(5):1181-1193.

8. Cao G, Ying Cheng , Zheng X , Wei H, Tian Z, Sun R*, Sun H*.All-trans retinoic acid induces leukemia resistance to NK cell cytotoxicity by down-regulating B7-H6 expression via c-Myc signaling. Cancer Commun.2021 Jan;41(1):51-61.

9. Hao X, Chen Y, Bai L, Wei H, Sun R*, Tian Z*. HBsAg-specific CD8+T cell as an indispensable trigger to induce murine hepatocellular carcinoma. Cell Mol Immunol. 2021 Jan;18(1):128-137.

11. Wu Y, Wang J, Zheng X, Chen Y, Huang M, Huang Q, Xiao W, Wei H, Tian Z, Sun R*, Sun C*. Establishment and Preclinical Therapy of Patient-derived Hepatocellular Carcinoma Xenograft Model.Immunol Lett. 2020 Jul;223:33-43.

12. Bai L, Peng H*, Hao X, Tang L, Sun C, Zheng M, Liu F, Lian Z, Bai L, Wei H, Sun R*, Tian Z*.CD8+ T Cells Promote Maturation of Liver-Resident NK Cells via the CD70-CD27 axis.Hepatology. 2019 Nov;70(5):1804-1815.

13. Zhang Q, Bi J, Zheng X, Chen Y, Wang H，Wu W, Wang Z, Wu Q, Peng H, Wei H, Sun R*, Tian Z*.Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nat Immunol.2018,19:723–732.

14. Wang X, Peng H*，Cong J, Wang X, Lian Z,Wei H, Sun R*& Tian Z*. Memory formation and long-term maintenance of IL-7Rα+ILC1s via a lymph node-liver axis.Nat Commun.2018;9:4854.

15. Li T, Wang J*, Wang Y, Chen Y, Wei H, Sun R*, Tian Z*. Respiratory Influenza Virus Infection Induces Memory-like Liver NK Cells in Mice.J Immunol.2017Feb 1;198(3):1242-1252.

16. He Y, Peng H, Sun R*, Wei H, Ljunggren HG, Yokoyama WM, Tian Z*. Contributionof inhibitory receptor TIGIT to NK cell education. J Autoimmun.2017 Jul;81:1-12.

17. Jiang W, Sun R, Wei H, Zhou R, Tian Z. Toll-like receptor 9 activation aggravates Con A-inducedhepatitis via promoting accumulation and activation of liver CD4+ NKT cells. J Immunol. 2009; 182:3768-74

18. Sun R, Park O, Horiguchi N, Kulkarni S, Jeong W-IL, Sun HY, Radaeva S and Gao B. STAT1 contributes to dsRNA inhibition if liver regeneration after partial hepatectomy in mice. Hepatology. 2006; 44: 955-966.

19. Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B. Natural Killer Cells Ameliorate Liver Fibrosis by Killing Activated Stellate Cells in NKG2D- dependent and tumour necrosis factor-related apoptosis-inducing ligand-dependent manners. Ganstroenterology. 2006; 130: 435-452

20. Sun R, Jaruga B, Kulkarni S, Sun HY and Gao B. IL-6modulates hepatocyte proliferation via inducytion of HCF/p21cip1: Regulation by SOCS3. Biochemical and Biophysical Research Communication. 2005; 338: 1943-1949

21. Sun R, Gao B. Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-gamma). Gastroenterology. 2004 Nov;127(5):1525-39.