魏海明教授

生命科学学院

电子邮箱

瀚海星云BBS

CMI杂志

中国科学技术大学

首页教授风采教授风采

魏海明教授

( 2020-05-27 )

实验室网站：http://ioi.ustc.edu.cn/whm_lab

魏海明，中国科学技术大学生命科学与医学部教授、博士生导师；中国科学技术大学生命科学与医学部常务副书记、副部长，党委常务副书记；2001年进入免疫所。中国免疫学会常务理事、肿瘤免疫与生物治疗专委会副主任委员，生殖免疫专委会副主任委员，安徽省免疫学会理事长。主持国家重点研发计划重点专项1项，基金委重点项目5项，863课题2项，973课题2项，国家新药创制重大专项1项。以通讯作者在Nat Immunol、Immunity、Cell Metab等发表SCI论文50余篇。

主要研究兴趣：

NK细胞亚群与重要疾病发生发展的关系；生殖免疫学，研究组织居留NK细胞（ThNK）与肿瘤、肝炎、

哮喘、自身免疫病等疾病的发生发展；基于天然免疫的肿瘤生物治疗技术。

主要在研课题：国家重点研发项目、国家自然科学基金重点项目、中国科学院先导项目。

主要代表论文：

1. Fang, X; Zhou, YG*; Chen, S ; Xu, XX ; Ke, JQ ; Zhou, Y ; Wei, HM; Fu, BQ*. Natural killer cells promote intra-cellular-infected trophoblasts survival via APOD-LRP1 axis. Immunology JAN 2023. DOI:10.1111/imm.13621

2. An, X; Qin, JK; Hu, XY ; Zhou, YG ; Fu, BQ ; Wei, HM*. Overexpression of lipocalin 2 in PBX1-deficient decidual NK cells promotes inflammation at the maternal-fetal interface.American Journal Of Reproductive Immunology. JAN.2023. DOI10.1111/aji.13676.

3. Zheng, XH *; Hou, ZH, Qian, YB ; Zhang, YW ; Cui, QW (Cui, Quanwei); Wang, XB; Shen, YQ ; Liu, ZB; Zhou, YG ; Fu, BQ，Sun, R; Tian, ZG*; Huang, GM *; Wei, HM *; Tumors evade immune cytotoxicity by altering the surface topology of NK cells. Nature Immunology. MAR 2023. DOI10.1038/s41590-023-01462-9

4. Chen, SY ; Li, WH ; Zheng, XH ; Yu, P ; Wang, PF ; Sun, ZT ; Xu, Y (Xu, Yao); Jiao, DF ; Ye, XY ; Cai, MC; Shen, MZ ; Wang, MQ ; Zhang, Q , Kong, F Wang, Y ; He, J ; Wei, HM ; Shi, FZ, ; Du, JF. Immunomagnetic microscopy of tumor tissues using sensors in diamond.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2022.Feb 1

5. Du, XH ; Zhu, HP; Jiao, DF; Nian, ZG ; Zhang, JH; Zhou, YG ; Zheng, XH ; Tong, XH ; Wei, HM ; Fu, BQHuman-Induced CD49a(+) NK Cells Promote Fetal Growth.FRONTIERS IN IMMUNOLOGY.2022.Feb.4;13

6. Xu, XX,Zhao, XR ; Chen, L ; Liu, MZY; Hu, ZM] ; Ke, JQ; Fu, BQ; Zhou, YG; Wei, HM.CD158a(+)/CD158b(+) NK cell imbalance correlates with hypertension in patients with pre-eclampsia.AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY.2022.Mar.87(5)

7. YonggangZhou; XiaoyuDing; HaimingWei. Reproductive immune microenvironment. Journal of Reproductive Immunology.2022 Aug;152:103654.

8. Xu, XX, Zhou YG, Fu GQ and Haiming Wei HM. Uterine NK cell functions at maternal-fetal interface†. Biology of Reproduction.2022 May. 107(1), 327–338.

9. Wang, HR; Liu, HL ; Zhou, L ; Wang, DY ; Wang, SS ; Liu, Q; Wu, Y ; Tu, MJ ; Sun, ZM ; Zheng, XH; Fu, BQ; Wang, BL ; Wei, HM.Cytomegalovirus-specific neutralizing antibodies effectively prevent uncontrolled infection after allogeneic hematopoietic stem cell transplantation. Journals & Books 2022.OTC 21. 25(10).

10. Guo, C ; Wu, MM ; Huang, BB ; Zhao, R ; Jin, LL ; Fu, BQ; Wang, P; Wang, DY ; Zheng, MJ; Fang, JW; Wei, HM; Qu, K ; Ni, F.Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19.GENOME MEDICINE.2022.May3.14(1)

11. Wang D, Sun Z, Zhu X, Zheng X, Zhou Y, Lu Y, Yan P, Wang H, Liu H, Jin J, Zhu H, Sun R, Wang Y, Fu B, Tian Z, Wei H*. GARP-mediated active TGF-β1 induces bone marrow NK cell dysfunction in AML patients with early relapse post-allo-HSCT. Blood. 2022 Aug 18; blood.2022015474

12. Dongyao Wang , Binqing Fu , Haiming Wei .Advances in Immunotherapy for Hepatitis B.Free PMC article2022 Sep 28;11(10):1116. doi: 10.3390/pathogens11101116.

13. Qiwu Bian .Binqing FuImmunological microenvironment at the maternal-fetal interface.Journal of Reproductive Immunology.2022 Jun;151:103632. doi: 10.1016/j.jri.2022.103632.

14. Leavenworth, JW (Leavenworth, Jianmei W. W.*) [1] , [2] , [3] ; Shi, LZ (Shi, Lewis Zhichang) [2] , [3] , [4] ; Wang, X (Wang, Xi)* [5] , [6] , [7] , [8] ; Wei, HM (Wei, Haiming) [9] , [10]*.Editorial: Immune Cell Lineage Reprogramming in Cancer.FRONTIERS IN IMMUNOLOGY.2022.JAN.12

15. Laihua Hu, Jinghe Zhang, Yichen Lu, Binqing Fu,*, Weiping Hu,* Estrogen receptor beta promotes endometriosis progression by upregulating CD47 expression in ectopic endometrial stromal cells . Journal of Reproductive Immunology. 2022 Jun. 151

16. Jiao D, Zheng X*, Du X, Wang D, Hu Z, Sun R, Tian Z, Fu B*, Wei H*.Immunogenic senescence sensitizes lung cancer to LUNX-targeting therapy. Cancer ImmunolImmunother. 2022 Jun;71(6):1403-1417.

17. Wang D#, Fu B#, Shen X, Guo C, Liu Y, Zhang J, Sun R, Ye Y, Li J*, Tian Z*, Wei H*. Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy. Signal Transduct Target Ther. 2021 Nov 5;6(1):376.

18. Jin L, Sun Z*, Liu H, Zhu X, Zhou Y, Fu B, Zheng X, Song K, Tang B, Wu Y, Zhu J, Sun R, Tian Z*, Wei H*. Inflammatory monocytes promote pre-engraftment syndrome and tocilizumab can therapeutically limit pathology in patients.Nat Commun. 2021 Jul 6;12(1):4137.

19. Nian Z, Zheng X*, Dou Y, Du X, Zhou L, Fu B, Sun R, Tian Z, Wei H*. Rapamycin Pretreatment Rescues the Bone Marrow AML Cell Elimination Capacity of CAR-T Cells.Clin Cancer Res. 2021 Nov 1;27(21):6026-6038.

20. Zhang J#, Wu H#, Yao X, Zhang D, Zhou Y, Fu B, Wang W, Li H, Wang Z, Hu Z, Ren Y, Sun R, Tian Z*, Bian X*, Wei H*. Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm. Cell Mol Immunol. 2021 May;18(5):1305-1307.

21. Zhou Y, Zhang J, Wang D, Wang D, Guan W, Qin J, Xu X, Fang J, Fu B, Zheng X, Wang D, Zhao H, Chen X, Tian Z, Xu X, Wang G*, Wei H*.Profiling of the immune repertoire in COVID-19 patients with mild, severe, convalescent, or retesting-positive status. J Autoimmun. 2021 Jan 14;118:102596.

22. Zhou Y, Wei H*. Tocilizumab is recommended for the treatment of severe COVID-19. EBioMedicine. 2020 Oct 7;61:103045.

23. Wang D, Cong J, Fu B, Zheng X, Sun R, Tian Z, Wei H*. Immunogenic chemotherapy effectively inhibits KRAS-Driven lung cancer. CancerLett. 2020 Aug 3;492:31-43.

24. Wei H*, Fu B*. Make killers sweeter:targeting metabolic checkpionts of NK cells. NatImmunol. 2020 Sep;21(9):970-971.

25. Fu B, Xu X, Wei H*. Why tocilizumab could be an effective treatment for severe COVID-19?J Transl Med. 2020 Apr 14;18(1):164.

26. Xu X#*, Han M#, Li T, Sun W, Wang D, Fu B, Zhou Y, Zheng X, Yang Y, Li X, Zhang X, Pan A, Wei H*. Effective Treatment of Severe COVID-19 Patients with Tocilizumab. Proc Natl Acad Sci. 2020 May;117(20).

27. Zhou Y#, Fu B#, Zheng X#, Wang D, Zhao C, qi Y, Sun R, Tian Z, Xu X*, Wei H*. Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients. NatlSciRev. 2020 Jun;7(6):998–1002.

28. Zhou Y, Fu B*, Xu X, Zhang J, Tong X, Wang Y, Dong Z, Zhang X, Shen N, Zhai Y, Kong X, Sun R, Tian Z*, Wei H*. PBX1 expression in uterine natural killer cells drives fetal growth. Sci Transl Med. 2020 Apr 1;12(537).

29. Xu X， Zhou Y，Fu B，Zhang J, Dong Z, Zhang X, Shen N, Sun R, Tian Z*, Wei H*. PBX1 promotes development of natural killer cells by binding directly to the Nfil3 promoter. FASEB J. 2020 May;34(5):6479-6492.

30. Zheng X, Qian Y, Fu B, Jiao D, Jiang Y, Chen P, Shen Y, Zhang H, Sun R, Tian Z*, Wei H*.Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance. Nat Immunol. 2019 Dec;20(12):1656-1667.

31. 2. Cong J, Wang X, Zheng X, Wang D, Fu B, Sun R, Tian Z*, Wei H*. Dysfunction of NK Cells by FBP1-induced Inhibition of Glycolysis during Lung Cancer Progression. Cell Metabolism. 2018, in press.

32. 3. Fu B#, Zhou Y#, Ni X#, Tong x, Xu X, Dong Z, Sun R, Tian Z*, Wei H*. Natural killer cells promote fetal development through the secretion of growth-promoting factors. Immunity. 2017, 47, 1100-1113 e1106. (#co-first authors; Cover Story)

33. Zheng X, Fan X, Fu B, Zheng M, Zhang A, Zhong K, Yan J, Sun R, Tian Z*, Wei H*. EpCAM inhibition sensitizes chemoresistant leukemia to immune surveillance. Cancer Res. 2016 Oct 3. pii: canres.0842.(Cover Story)

34. Zheng X, Cheng M, Fu B, Fan X, Wang Q, Yu X, Sun R, Tian Z*, Wei H*. Targeting LUNX inhibits non-small cell lung cancer growth and metastasis. Cancer Res. 2015 Mar 15;75(6):1080-90.

35. Lv S, Wang J, Dou S, Yang X, Ni X, Sun R, Tian Z*, Wei H*. Nanoparticles encapsulating hepatitis B virus cytosine-phosphate-guanosine induce therapeutic immunity against HBV infection. Hepatology. 2014;59(2):385-94.

36. Ni F, Sun R, Fu B, Wang F, Guo C, Tian Z*, Wei H*. IGF-1 promotes the development and cytotoxic activity of human NK cells. Nat Commun. 2013; 4:1479.

37. Fu B, Li X, Sun R, Tong X, Ling B, Tian Z*, Wei H*. Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface. Proc Natl Acad Sci USA. 2013;110(3):E231-40.

38. Li F, Wei H, Wei H*, Gao Y, Xu L, Yin W, Sun R, Tian Z*. Blocking the Natural Killer Cell Inhibitory Receptor NKG2A Increases Activity of Human Natural Killer Cells and Clears Hepatitis B Virus Infection in Mice. Gastroenterology. 2013;144(2):392-401

39. 10. Sun C, Fu B, Gao Y, Liao X, Sun R, Tian Z*, Wei H*. TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. PLoSPathog. 2012;8(3):e1002594.

40. 11. Zhang J, Huang Z, Sun R, Tian Z*, Wei H*. IFN-γ induced by IL-12 administration prevents diabetes by inhibiting pathogenic IL-17 production in NOD mice. J Autoimmun. 2012;38(1):20-8.

ResearcherID：http://www.researcherid.com/rid/G-7703-2018

联系方式：

办公电话: 0551-63607379;

传真: 0551-63606783;

E-mail: ustcwhm@ustc.edu.cn