孙宝林教授

生命科学学院

电子邮箱

瀚海星云BBS

CMI杂志

中国科学技术大学

首页教授风采教授风采

孙宝林教授

( 2020-05-28 )

实验室网站：http://sunlab.ustc.edu.cn

孙宝林，中国科学技术大学生命科学与医学部教授，合肥微尺度物质科学国家实验室研究员。中国科学技术大学生物安全实验室执行主任；中国科大先研院-卓源健康人体微生物组研究联合实验室主任。1999年于美国密歇根州立大学（Michigan State University）获得微生物学博士学位，并在1999年-2002年，于密歇根州立大学任研究助理教授。主要研究成果发表于Science，PLoS Pathog和ASM（American Society for Microbiology）期刊等国际高水平杂志。2004年，入选中国科学院“人才计划”，并于同年评为教育部新世纪优秀人才。

主要研究兴趣：重要致病细菌群体感应与生物膜发育及致病机理；细菌非编码小RNA调控的细胞行为。

发表SCI论文情况：

53. Li Y, Pan T, Cao R, Li W, He Z, Sun B (2023). Nitrate Reductase NarGHJI Modulates Virulence via Regulation of agr Expression in Methicillin-Resistant Staphylococcus aureus Strain USA300 LAC. Microbiology Spectrum.03596-22.

52. Shu X, Shi Y, Huang Y, Yu D, Sun B (2023). Transcription tuned by S-nitrosylation underlies a mechanism for Staphylococcus aureus to circumvent vancomycin killing. Nat Commun 14, 2318.

51. Cao J, Zhang H, He Z, Piao Z, Zong X, Sun B (2023). Genotypic and Phenotypic Characterization of Some psms Hypervirulent Clinical Isolates of Staphylococcus aureus in a Tertiary Hospital in Hefei, Anhui. Infect Drug Resist. 16:1471-1484..

50. Zhang H, Cao J, He Z, Zong X, Sun B (2023). Molecular Epidemiology of Staphylococcus aureus in a Tertiary Hospital in Anhui, China: ST59 Remains a Serious Threat. Infect Drug Resist 16:961-976.

49. Zhao H, He Z, Li Y, Sun B (2022). Epidemiology of carbapenem-resistant Klebsiella pneumoniae ST15 of producing KPC-2, SHV-106 and CTX-M-15 in Anhui, China. BMC Microbiol 22(1):262.

48. He Z, Xu W, Zhao H, Li W, Dai Y, Lu H, Zhao L, Zhang C, Li Y, Sun B (2022). Epidemiological characteristics an outbreak of ST11 multidrug-resistant and hypervirulent Klebsiella pneumoniae in Anhui, China. Front Microbiol 13:996753.

47. Liu D, Zhang R, Chen S, Sun B, Zhang K (2022). Analysis of gastric microbiome reveals three distinctive microbial communities associated with the occurrence of gastric cancer. BMC Microbiol 22(1):184.

46. He Z, Yang Y, Li W, Ma X, Zhang C, Zhang J, Sun B, Ding T, Tian GB (2022). Comparative genomic analyses of Polymyxin-resistant Enterobacteriaceae strains from China. BMC Genomics 23:88.

45. Pan T, Guan J, Li Y and Sun B (2021). LcpB Is a Pyrophosphatase Responsible for Wall Teichoic Acid Synthesis and Virulence in Staphylococcus aureus Clinical Isolate ST59. Front Microbiol 12:788500.

44. Liu D, Chen S, Zhang R, Wang J, Gou Y, Yu W, Zhou H, Ye F, Liu Y, Sun B, Zhang K (2021). Gastrointestinal microbiota changes in patients with gastric precancerous lesions. Front Cell Infect Microbiol 11:749207.

43. Wang W, Sun B (2021). VraCP Regulates Cell Wall Metabolism and Antibiotic Resistance in Vancomycin-intermediate Staphylococcus aureus Strain Mu50. Journal of Antimicrobial Chemotherapy 76:1712-1723.

42. Zhu J, Liu B, Shu X, Sun B (2021). A novel mutation of walK confers vancomycin resistance in methicillin-susceptible Staphylococcus aureus. Int J Med Microbiol 311:151473.

41. Xue L, Yue J, Ke J, Khan M, Wen W, Sun B, Zhu Z, Niu L (2020). Distinct oligomeric structures of the YoeB–YefM complex provide insights into the conditional cooperativity of type II toxin–antitoxin system. Nucleic Acids Research 48: 10527–10541.

40. Jin Z, Li W, Wang W, Sun B (2020). Complete genome sequence of Bifidobacterium adolescentis ZJ2, isolated from a centenarian in Anhui, China. Microbiol Resour Announc 9:e00710-20.

39. Zong X, Liu D, Li M, Sun B (2020). Complete genome sequence of community-acquired methicillin-resistant Staphylococcus aureus Strain RJ1267, isolated in Shanghai, China. Microbiol Resour Announc 9:e00244-20.

38. Fang B, Liu B, Sun B (2020). Transcriptional regulation of virulence factors Hla and phenolsoluble modulins α by AraC-type regulator Rbf in Staphylococcus aureus. Int J Med Microbiol 310:151436.

37. Zhu Q, Liu B, Sun B (2020). SpoVG modulates cell aggregation by regulating sasC expression and eDNA release in Staphylococcus aureus. Appl Environ Microbiol 86:e00591-20.

36. Liu B, Sun B (2020). Rsp promotes the transcription of virulence factors in an agr-independent manner in Staphylococcus aureus. Emerging Microbes & Infections 9:796-812.

35. Habib G, Zhu J, Sun B (2020). A novel type I toxin-antitoxin system modulates persister cell formation in Staphylococcus aureus. Int J Med Microbiol 310:151400.

34. Jin Z, Li W, Wang W, Sun B (2019). Draft Genome Sequence of Bifidobacterium longum ZJ1, isolated from a Centenarian in Anhui, China. Microbiol Resour Announc 8:e00878-19.

33. Jin Z, Jiang Q, Fang B, Sun B (2019). The ArlR-MgrA regulatory cascade regulates PIA-dependent and protein-mediated biofilm formation in Rbf-dependent and Rbf-independent pathways. Int J Med Microbiol 309:85-96.

32. Zhu Q, Wen W, Wang W, Sun B (2019). Transcriptional regulation of virulence factors Spa and ClfB by the SpoVG-Rot cascade in Staphylococcus aureus. Int J Med Microbiol 309:39–53.

31. Habib G, Zhu Q, Sun B (2018). Bioinformatics and functional assessment of toxin-antitoxin systems in Staphylococcus aureus. Toxins 10:73.

30. Jiang Q, Jin Z, Sun B (2018). MgrA negatively regulates biofilm formation and detachment by repressing the expression of psm operons in Staphylococcus aureus. Appl Environ Microbiol 84:e01008-18.

29. Wen W, Liu B, Xue L, Zhu Z, Niu L, Sun B (2018). Autoregulation and virulence control by the toxin-antitoxin system SavRS in Staphylococcus aureus. Infect Immun 86:e00032-18.

28. Guan J, Wang W, Sun B (2017). Chromosomal targeting by the type III-A CRISPR-Cas system can reshape genomes in Staphylococcus aureus. mSphere 2:e00403-17.

27. Ma R, Qiu S, Jiang Q, Sun H, Xue T, Cai G, Sun B (2017). AI-2 quorum sensing negatively regulates rbf expression and biofilm formation in Staphylococcus aureus. Int J Med Microbiol 307:257-267.

26. Zhao C, Shu X, Sun B (2017). Construction of a gene knockdown system based on catalytically inactive ('dead') Cas9 (dCas9) in Staphylococcus aureus. Appl Environ Microbiol 83:e00291-17.

25. Cao L, Gao C, Zhu J, Zhao L, Wu Q, Li M, Sun B (2016). Identification and functional study of type III-A CRISPR-Cas systems in clinical isolates of Staphylococcus aureus. Int J Med Microbiol 306:686-696.

24. Wang Y, Ma H, Yin X, Wang Y, Liu Q, Yang J, Shi Q, Sun B, Gershwin M, Lian Z (2016). Forkhead Box O1 regulates macrophage polarization following Staphylococcus aureus infection: experimental murine data and review of the literature. Clinic Rev Allerg Immunol 51:353-369.

23. Zhang S, Shu X, Sun B (2016). SigmaB regulates ccrAB expression and SCCmec excision in methicillin-resistant Staphylococcus aureus. Int J Med Microbiol 306:406-414.

22. Liu X, Zhang S, Sun B (2016). SpoVG regulates cell wall metabolism and oxacillin resistance in methicillin-resistant Staphylococcus aureus strain N315. Antimicrob Agents Chemother 60:3455–3461.

21. Yang Y, Sun H, Liu X, Wang M, Xue T, Sun B (2016). Regulatory mechanism of the three-component system HptRSA in glucose-6-phosphate uptake in Staphylococcus aureus. Med Microbiol Immunol 205:241-253.

20. Zhang S, Ma R, Liu X, Zhang X, Sun B (2015). Modulation of ccrAB expression and SCCmec excision by an inverted repeat element and SarS in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 59:6223-6232.

19. Fan X, Zhang X, Zhu Y, Niu L, Teng M, Sun B, Li X. (2015). Structure of the DNA-binding domain of the response regulator SaeR from Staphylococcus aureus. Acta Cryst D71:1768-1776.

18. Chen C, Zhang X, Shang F, Sun H, Sun B, Xue T (2015). The Staphylococcus aureus protein-coding gene gdpS modulates sarS expression via mRNA-mRNA interaction. Infect Immun 83:3302-3310.

17. Zhang X, Zhu Q, Tian T, Zhao C, Zang J, Xue T, Sun B (2015). Identification of RNAIII-binding proteins in Staphylococcus aureus using tethered RNAs and streptavidin aptamers based pull-down assay. BMC Microbiol 15:102.

16. Bao Y, Zhang X, Jiang Q, Xue T, Sun B (2015). Pfs promotes autolysis-dependent release of eDNA and biofilm formation in Staphylococcus aureus. Med Microbiol Immunol 204:215-226.

15. Hu J, Zhang X, Liu X, Chen C, Sun B (2015). Mechanism of reduced vancomycin susceptibility conferred by walK mutation in community-acquired methicillin-resistant Staphylococcus aureus strain MW2. Antimicrob Agents Chemother 59:1352-1355.

14. You Y, Xue T, Cao L, Zhao L, Sun H, Sun B (2014). Staphylococcus aureus glucose-induced biofilm accessory proteins, GbaAB, influence biofilm formation in a PIA-dependent manner. Int J Med Microbiol 304:603-612.

13. Xue T, Zhang X, Sun H, Sun B (2014). ArtR, a novel sRNA of Staphylococcus aureus, regulates α-toxin expression by targeting the 5' UTR of sarT mRNA. Med Microbiol Immunol 203:1-12.

12. Sun H, Yang Y, Xue T, Sun B (2013). Modulation of cell wall synthesis and susceptibility to vancomycin by the two-component system AirSR in Staphylococcus aureus NCTC8325. BMC Microbiol 13:286.

11. Hong Y, Zhou X, Fang H, Yu D, Li C, Sun B (2013). Cyclic di-GMP mediates Mycobacterium tuberculosis dormancy and pathogenecity. Tuberculosis 93:625-634.

10. Fang H, Yu D, Hong Y, Zhou X, Li C, Sun B (2013). The LuxR family regulator Rv0195 modulates Mycobacterium tuberculosis dormancy and virulence. Tuberculosis 93:425-431.

9. Bao Y, Li Y, Jiang Q, Xue T, Hu B, Sun B (2013).Methylthioadenosine/S-adenosylhomocysteine nucleosidase (Pfs) of Staphylococcus aureus is essential for the virulence independent of LuxS/AI-2 system. Int J Med Microbiol 303:190-200.

8. Xue T, Zhao L, Sun B (2013). LuxS/AI-2 system is involved in antibiotic susceptibility and autolysis in Staphylococcus aureus NCTC8325. Int J Antimicrob Agents 41:85-89.

7. Yu D, Zhao L, Xue T, Sun B (2012). Staphylococcus aureus autoinducer-2 quorum sensing decreases biofilm formation in an icaR-dependent manner. BMC Microbiol 12:288.

6. Xiong M, Bao Y, Yang X, Wang Y, Sun B, Wang J (2012). Lipase-sensitive polymeric triple-layered nanogel for 'on-demand' drug delivery. J Am Chem Soc 134:4355-4362.

5. Xue T, You Y, Shang F, Sun B (2012). Rot and Agr system modulate fibrinogen-binding ability mainly by regulating clfB expression in Staphylococcus aureus NCTC8325. Med Microbiol Immunol 201:81-92.

4. Xue T, You Y, Hong D, Sun H, Sun B (2011). The Staphylococcus aureus KdpDE two-component system couples extracellular K+ sensing and Agr signaling to infection programming. Infect Immun 79:2154-2167.

3. Zhao L, Xue T, Shang F, Sun H, Sun B (2010). Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence. Infect Immun 78:3506-3515.

2. Tao L, Wu X, Sun B (2010). Alternative sigma factor σH modulates prophage integration and excision in Staphylococcus aureus. PLoS Pathog 6:e1000888.

1. Shang F, Xue T, Sun H, Xing L, Zhang S, Yang Z, Zhang L, Sun B (2009). The Staphylococcus aureus GGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner. Infect Immun 77:2849-2856.