孙成教授

生命科学学院

电子邮箱

瀚海星云BBS

CMI杂志

中国科学技术大学

首页教授风采教授风采

孙成教授

( 2022-02-23 )

孙成，教授，中国科学技术大学附属第一医院移植与免疫实验室科研主任。2006年毕业于安徽医科大学，获医学学士学位，2007至2012年在中国科学技术大学生命科学学院免疫所硕博连读，获理学博士学位。2012至2014年在中国科学技术大学生命科学学院从事博士后研究工作。主要研究领域：固有免疫。以第一作者/通讯作者在Nat Commun、PLoS Pathog、Cell Mol Immunol、Hepatology等学术期刊上发表论文多篇。作为负责人主持国家自然科学基金面上/青年、中国博士后科学创新基金、安徽省自然科学基金等多项课题，2020年获安徽省杰出青年基金资助。

主要研究兴趣：1. 共抑制因子诱导NK细胞功能耗竭;2. HBV介导肝癌的免疫逃逸机制。

主要代表文章：

1. Wu, H., He, P., Ren, Y., Xiao, S., Wang, W., Liu, Z., Li, H., Wang, Z., Zhang, D., Cai, J., Zhou, X., Jiang, D., Fei, X., Zhao, L., Zhang, H., Liu, Z., Chen, R., Li, W., Wang, C., Zhang, S., Qin, J., Björn, N & Sun, C,.Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation. Nat Commun 13, 269 (2022). https://doi.org/10.1038/s41467-021-27723-5.

2. Sajid M, Liu L and Sun C (2022). The Dynamic Role of NK Cells in Liver Cancers: Role in HCC and HBV Associated HCC and Its Therapeutic Implications. Front. Immunol. 13:887186. doi: 10.3389/fimmu.2022.887186.

3. Hu B, Sajid M, Lv R, Liu L and Sun C (2022). A review of spatial profiling technologies for characterizing the tumor microenvironment in immuno-oncology. Front. Immunol. 13:996721. doi: 10.3389/fimmu.2022.996721.

4. Yuan X, Rasul F, Nashan B, Sun C. Innate lymphoid cells and cancer: Role in tumor progression and inhibition. Eur J Immunol. 2021 Sep;51(9):2188-2205. doi: 10.1002/eji.202049033. Epub 2021 Jul 11. PMID: 34189723; PMCID: PMC8457100.

5. Yuwei Wu(#), Jinyu Wang(#), Xiaodong Zheng, Yongyan Chen, Mei Huang, Qiang Huang, Weihua Xiao, Haiming Wei, Zhigang Tian, Rui Sun(*)，Sun C(*) Establishment and Preclinical Therapy of Patient-derived Hepatocellular Carcinoma Xenograft Model. Immunol Lett. Volume 223, July 2020.

6. Yin S, Qin J, Zhou Q, Zhu C, Li Y, Wu D, Shen Z, Guo Y, Zhou Y, Nashan B. Sequential metastasis to the liver and pancreas 4 years after gestational trophoblastic neoplasia: a case report. J Int Med Res. 2020 Nov;48(11):300060520966807.

7. Sun H, Huang Q, Huang M, Wen H, Lin R, Zheng M, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z*, Sun C* . Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma. Hepatology. 2019 Jul;70(1):168-183.

8. Sun H, Xu J, Huang Q, Huang M, Li K, Qu K, Wen H, Lin R, Zheng M, Wei H, Xiao W, Sun R,Tian Z*, Sun C*. Reduced CD160 expression contributes to impaired NK cell function and poor clinical outcomes in patients with HCC. Cancer Res. 2018 Dec 1;78(23):6581-6593.

9. Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G ,Song J, Wang J, Wei H, Zhang J, Sun R, Zhang C*, Tian Z*. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nat Commun. 2018 Mar 28;9(1):1241.

10.Sun H, Song J, Weng C, Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C. Decreased expression of the macrophage scavenger receptor MARCO is associated with tumour progression and poor prognosis in human hepatocellular carcinoma. J Gastroenterol Hepatol. 2017 May;32(5):1107-1114.

11.Sun H, Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C. CD200R, a co-inhibitory receptor on immune cells, predicts the prognosis of human hepatocellular carcinoma.Immunol Lett. 2016 Oct;178:105-13.

12.Sun C, Sun HY, Xiao WH, Zhang C, Tian ZG. Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy. Acta Pharmacol Sin. 2015 Oct;36(10):1191-9.

13.Sun C, Xu J, Huang Q, Huang M, Wen H, Zhang C, Wang J, Song J, Zheng M, Sun H, Wei H, Xiao W, Sun R, Tian Z. High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer. Oncoimmunology. 2016 Dec 7; 6(1): e1264562.

14.Sun C, Sun H, Zhang C, Tian Z. NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma. Cell Mol Immunol. 2015 May;12(3):292-302.

15.Sun C, Fu B, Gao Y, Liao X, Sun R, Tian Z, Wei H. TGF-beta1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. PLoS Pathog. 2012;8(3):e1002594.