中国科学技术大学生命科学学院免疫学研究所
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王毅 研究员
( 2023-05-26 )

  


  实验室网站:http://jcyx.ustc.edu.cn/2021/0827/c24419a520911/page.htm

王毅,特任研究员, 博士生导师。中国科学技术大学生命科学与医学部,基础医学院/附属第一医院(肝胆胰外科),双聘青年杰出人才。微尺度国家研究中心分子医学部/中科院天然免疫与慢性病重点实验室PI,2020年起组建免疫学/化学生物学交叉研究实验室。系列工作以通讯作者发表在EMBO Reports,J. Am. Chem. Soc.等上,以第一/共第一作者发表在Nature、PNAS、Cell Chem Biol、eLife等国际期刊上。主持承担2020,2023年国家自然科学基金面上项目。主持承担2023-2026综合性国家科学中心合肥大健康研究院,全球遴选项目(创新药物类)等。

 

主要研究兴趣:

    运用化学生物学、免疫学和结构生物学等Bio-X多学科交叉技术研究,如NK细胞的肿瘤免疫

和 NK细胞合成免疫学。

主要代表文章:

1.      Jing Jin#,* Lin Bai#, Dongyao Wang#, Wei Ding, Zhuoxian Cao, Peidong Yan, Yunjia Li, Lulu Xi, Yuxin Wang, Xiaohu Zheng, Haiming Wei, Chen Ding, * Yi Wang *. SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth. EMBO Reports, 2023. (Impact Factor: 9.421)

2.      Yunjia Li, Jing Jin,Yi Wang.* SIRT6 Widely Regulates Aging, Immunity, and Cancer. Front. Oncol., 06 April 2022. (Impact Factor: 5.738)

3.      Jing Jin, Bin He, Xiaoyu Zhang, Hening Lin, * Yi Wang. * SIRT2 reverses 4-oxononanoyl lysine modification on histones. J. Am. Chem. Soc., 2016, 138 (38), pp 12304–12307. (Impact Factor: 16.383)

4.      Yi Wang#, Jing Jin#, Matthew Wai Heng Chung#, Ling Feng, Hongyan Sun, Quan Hao. Identificationof the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation. Proc Natl Acad Sci U S A. 2018, Feb 20. pii: 201717664.  

5.      Yi Wang, Yi Man Eva Fung, Weizhe Zhang, Bin He, Matthew Wai Heng Chung, Jing Jin, Jing Hu, Hening Lin, Quan Hao. De-acylation Mechanism by SIRT2 Revealed in an Intermediate Structure. Cell Chemical Biology, 2017. 16; 24(3): 339-345.

6.      Xiucong Bao#, Yi Wang#, Xin Li#, Xiao-Meng Li#, Zheng Liu, Tangpo Yang, Chi Fat Wong, Jiangwen Zhang, Quan Hao, Xiang David Li. Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach. eLife. 2014; 3: e02999.  

7.      Hong Jiang#, Saba Khan#, Yi Wang#, Guillaume Charron, Bin He, Carlos Sebastian, Jin tang Du, Ray Kim, Eva Ge, Raul Mostoslavsky, Howard C. Hang, Quan Hao & Hening Lin. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature. 2013, 496, (110–113). 

8.      He Huang, Di Zhang, Yi Wang, Mathew Perez-Neut, Zhen Han, Y. George Zheng, Quan Hao & Yingming Zhao. Lysine benzoylation is a histone mark regulated by SIRT2. Nature Communications, 2018, v. 9 n. 1, p. 3374

9.      Zhen Tong, Miao Wang, Yi Wang, David D. Kim, Jennifer K. Grenier, Ji Cao, Sushabhan Sadhukhan, Quan Hao, and Hening Lin. SIRT7 is an RNA-activated protein lysine deacylase. ACS Chem. Biol. 2016, DOI: 10.1021/acschembio.6b00954.

10.   Yusheng Xie, Jingyan Ge, Haipeng Lei, Bo Peng, Huatang Zhang, Danyang Wang, Sijun Pan, Ganchao Chen, Lanfang Chen, Yi Wang, Quan Hao, Shao Q. Yao, Hongyan Sun. Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases. J. Am. Chem. Soc., 2016, 138 (48), pp 15596–15604

11.   Zhen Tong, Yi Wang, Xiaoyu Zhang, David D. Kim, Sushabhan Sadhukhan, Quan Hao, Hening Lin*. SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context. ACS Chem. Biol. 2016, 11, 742−747

12.   Shrestha Ghosh, Baohua Liu, Yi Wang, Quan Hao, Zhongjun Zhou. Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair. Cell report. 2015, 1396–1406 

13.   Yi Wang, Yong-Xing He, Jiang Yu and Cong-Zhao Zhou*. Cloning, overproduction, purification, crystallization and preliminary X-ray diffraction analysis of yeast glutaredoxin Grx5. Acta Crystallographica Section F, 2009, ISSN 1744-3091

 

四. 联系方式

欢迎致力于免疫学/化学生物学交叉研究的本科生来本实验室攻读博士学位。实验室长期招聘博士后和科研助理,有意者请将个人简历(包括个人基本信息、教育和工作经历、论文发表其他成果)发至邮箱:wy83@ustc.edu.cn,联系电话:0551-63603117,                 http://jcyx.ustc.edu.cn/2021/0827/c24419a520911/page.htm


 




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