Zhigang Tian, Ph.D.

Professor & Director, Institute of Immunology

Dean, School of Life Scinces

University of Science & Technology of China

Education and Appointment

05/2001-present: Professor, Univ Sci Tech China, China

04/1989-05/2001: Assist/Asso/Full Professor, Shandong Acad Med Sci, China

03/1986-03/1989: Ph.D., Immunology, Normal Bethune Med Univ, China

03/1983-08/1985: M.S.,Immunol,Shandong Acad Med Sci, China

03/1978-12/1982: Bachelor of Medicine, Shanxi Medical University, China

05/2002-04/2003: Visiting Professor, Kanazawa Univ Cancer Inst, Japan

1/2002-4/2002: Visiting Scientist, NIAAA, NIH, USA

2/1999-8/1999: Visiting Professor, Med College Virginia, Richmond, USA

8/1994-6/1996: Visiting Scientist, NCI, NIH, USA

Speciality & Research Field of Interest

NK cells, Liver Immunology and major diseases (cancer, infection and autoimmunity)

Selected Publications

1.Jin Z, Sun R, Wei H, Gao X, Chen Y, Tian Z. Accelerated Liver Fibrosis in Hepatitis B Virus Transgenic Mice: Involvement of Natural Killer T Cells. Hepatology 2010 Sep; In press

2. Jiang W, Sun R, Wei H, Zhou R, Tian Z. Toll-like receptor 9 activation aggravates Con A-inducedhepatitis via promoting accumulation and activation of liver CD4+ NKT cells. J Immunol 2009; 182:3768-74

3. Hou X, Zhou R, Wei H, Sun R, Tian Z. NKG2D-Rea 1 recognition between natural killer cells and kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis.. Hepatology 2009; 49:940-9

4. Wei HX, Chuang YH, Li B, Wei H, Sun R, Moritoki Y, Gershwin ME, Lian ZX, Tian Z. CD4+ CD25+ 　

Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice. J Immunol. 2008;181:7221-9

5. Chen QF, Wei HM, Sun R, Zhang J, Tian Z. Therapeutic RNA silencing of CX3CL1 gene prevents 　

mice from adenovirus vector-induced acute liver injury. Hepatology 2008; 47:648-58

6. Chen Y, Wei H, Sun R, Dong Z, Zhang J, Tian Z. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. Hepatology 2007; 46(3):706-15.

7. Zhou R, Wei H, Sun R, Tian ZG. NKG2D Recognition Mediates TLR3 Signaling-Induced Breakdown of Epithelial Homeostasis in Acute Small Intestine Injury of Mice. Proc Natl Acad Sci USA. 2007; 104:7512-5.

8. Dong Z, Zhang J, Sun S, Wei H, Tian ZG. Impairment of liver regeneration correlates with over-activated hepatic NKT cells in HBV transgenic mice. Hepatology 2007; 45:1400-12.

9. Li B, Sun R, Wei H, Gao B, Tian ZG. Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism. Hepatology 2006; 43:1211-9. 

10. Jiang W, Sun R, Wei HM, Tian ZG. Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages. Proc Natl Acad Sci USA 2005; 102: 17077-17082.